An environmentally benign process for the hydrogenation of ketones with homogeneous iron catalysts

被引：113

作者：

Enthaler, Stephan ^{[1
]}

Hagemann, Bernhard ^{[1
]}

Erre, Giulia ^{[1
]}

Junge, Kathrin ^{[1
]}

Beller, Matthias ^{[1
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

来源：

CHEMISTRY-AN ASIAN JOURNAL | 2006年 / 1卷 / 04期

关键词：

homogeneous catalysis; iron; ketones; ligand effects; transfer hydrogenation;

D O I：

10.1002/asia.200600105

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Iron complexes generated in situ catalyze homogeneously the transfer hydrogenation of aliphatic and aromatic ketones by utilizing 2-propanol as a hydrogen donor in the presence of base. The influence of different reaction parameters on the catalytic activity is investigated in detail by applying a three-component catalyst system composed of an iron salt, 2,2':6',2"-terpyridine, and PPh3. The scope and limitations of the described catalyst is shown in the reduction of 11 different ketones. In most cases, high conversion and excellent chemoselectivity are obtained. Mechanistic studies indicate a monohydride reaction pathway for the homogeneous iron catalyst.

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页码：598 / 604

页数：7

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