Substitution in position 222 of haemagglutinin of pandemic influenza A (H1N1) viruses isolated from pigs in Poland

被引：0

作者：

Kowalczyk, Andrzej ^{[1
]}

Urbaniak, Kinga ^{[1
]}

Markowska-Daniel, Iwona ^{[1
]}

Pejsak, Zygmunt ^{[1
]}

机构：

[1] Natl Inst Vet Res, Dept Swine Dis, PL-24100 Pulawy, Poland

来源：

BULLETIN OF THE VETERINARY INSTITUTE IN PULAWY | 2015年 / 59卷 / 04期

关键词：

swine influenza virus; mutagenesis; pandemic influenza; RECEPTOR SPECIFICITY; GENETIC DIVERSITY; VIRULENCE; MUTATION;

D O I：

10.1515/bvip-2015-0066

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The aim of the study was to monitor genetic diversity and antigenic changes in the genome of influenza A(H1N1)pdm09 viral isolates detected during the post-pandemic period in Poland. Clinical specimens obtained from three suspected cases of influenza were analysed by sequencing. Among the differences identified in amino acids sequences, nine substitutions were located within the antigenic HA1 sites and in five residues forming receptor-binding pocket. The HA(D222G) mutation was shown in the isolate Swine/Poland/134312/12 obtained from a mild case of the disease. It must be emphasized that, in general, clinically mild cases are caused by the viruses in which that specific mutation, i.e. haemagglutinin (D222G), does not occur.

引用

页码：451 / 455

页数：5

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