Rapid selection and archiving of mutation E157Q in HIV-1 DNA during short-term low-level replication on a raltegravir-containing regimen

被引：15
作者：
Ghosn, Jade [1 ,2 ]
Mazet, Anne-Aurelie [3 ]
Avettand-Fenoel, Veronique [1 ]
Peytavin, Gilles [4 ]
Wirden, Marc [5 ]
Delfraissy, Jean-Francois [2 ]
Chaix, Marie-Laure [1 ]
机构：
[1] Paris Descartes Univ, EA 3620, Dept Virol, AP HP,Necker Univ Hosp, Paris, France
[2] Bicetre Univ Hosp, AP HP, Dept Internal Med & Infect Dis, Le Kremlin Bicetre, France
[3] Bicetre Univ Hosp, AP HP, Dept Virol, Le Kremlin Bicetre, France
[4] Bichat Claude Bernard Univ Hosp, AP HP, Dept Clin Pharmacol, Paris, France
[5] Hop La Pitie Salpetriere, AP HP, Dept Virol, Paris, France
来源：
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2009年 / 64卷 / 02期
关键词：
antiretroviral therapy; HIV; resistance; TREATMENT-EXPERIENCED PATIENTS; INFECTION; STRAINS;
D O I：
10.1093/jac/dkp182
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
引用
收藏
页码：433 / 434
页数：2
相关论文
共 8 条
[1]   Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection [J].
Cooper, David A. ;
Steigbigel, Roy T. ;
Gatell, Jose M. ;
Rockstroh, Jurgen K. ;
Katlama, Christine ;
Yeni, Patrick ;
Lazzarin, Adriano ;
Clotet, Bonaventura ;
Kumar, Princy N. ;
Eron, Joseph E. ;
Schechter, Mauro ;
Markowitz, Martin ;
Loutfy, Mona R. ;
Lennox, Jeffrey L. ;
Zhao, Jing ;
Chen, Joshua ;
Ryan, Desmond M. ;
Rhodes, Rand R. ;
Killar, John A. ;
Gilde, Lucinda R. ;
Strohmaier, Kim M. ;
Meibohm, Anne R. ;
Miller, Michael D. ;
Hazuda, Daria J. ;
Nessly, Michael L. ;
DiNubile, Mark J. ;
Isaacs, Robin D. ;
Teppler, Hedy ;
Nguyen, Bach-Yen .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :355-365
[2]   HIV-1 resistant strains acquired at the time of primary infection massively fuel the cellular reservoir and persist for lengthy periods of time [J].
Ghosn, J ;
Pellegrin, I ;
Goujard, C ;
Deveau, C ;
Viard, JP ;
Galimand, J ;
Harzic, M ;
Tamalet, C ;
Meyer, L ;
Rouzioux, C ;
Chaix, ML .
AIDS, 2006, 20 (02) :159-170
[3]   Evidence of genotypic resistance diversity of archived and circulating viral strains in blood and semen of pre-treated HIV-infected men [J].
Ghosn, J ;
Viard, JP ;
Katlama, C ;
de Almeida, M ;
Tubiana, R ;
Letourneur, F ;
Aaron, L ;
Goujard, C ;
Salmon, D ;
Leruez-Ville, M ;
Rouzioux, C ;
Chaix, ML .
AIDS, 2004, 18 (03) :447-457
[4]   Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial [J].
Grinsztejn, Beatriz ;
Nguyen, Bach-Yen ;
Katlama, Christine ;
Gatell, Jose M. ;
Lazzarin, Adriano ;
Vittecoq, Daniel ;
Gonzalez, Charles J. ;
Chen, Joshua ;
Harvey, Charlotte M. ;
Isaacs, Robin D. .
LANCET, 2007, 369 (9569) :1261-1269
[5]  
Katlama C, 2008, ANTIVIR THER, V13, pA13
[6]  
KUIKEN C, 2008, HIV SEQUENCE COMPEND, P328
[7]   Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro [J].
Malet, Isabelle ;
Delelis, Olivier ;
Valantin, Marc-Antoine ;
Montes, Brigitte ;
Soulie, Cathia ;
Wirden, Marc ;
Tchertanov, Luba ;
Peytavin, Gilles ;
Reynes, Jacques ;
Mouscadet, Jean-Francois ;
Katlama, Christine ;
Calvez, Vincent ;
Marcelin, Anne-Genevieve .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2008, 52 (04) :1351-1358
[8]   Raltegravir with optimized background therapy for resistant HIV-1 infection [J].
Steigbigel, Roy T. ;
Cooper, David A. ;
Kumar, Princy N. ;
Eron, Joseph E. ;
Schechter, Mauro ;
Markowitz, Martin ;
Loutfy, Mona R. ;
Lennox, Jeffrey L. ;
Gatell, Jose M. ;
Rockstroh, Jurgen K. ;
Katlama, Christine ;
Yeni, Patrick ;
Lazzarin, Adriano ;
Clotet, Bonaventura ;
Zhao, Jing ;
Chen, Joshua ;
Ryan, Desmond M. ;
Rhodes, Rand R. ;
Killar, John A. ;
Gilde, Lucinda R. ;
Strohmaier, Kim M. ;
Meibohm, Anne R. ;
Miller, Michael D. ;
Hazuda, Daria J. ;
Nessly, Michael L. ;
DiNubile, Mark J. ;
Isaacs, Robin D. ;
Nguyen, Bach-Yen ;
Teppler, Hedy .
NEW ENGLAND JOURNAL OF MEDICINE, 2008, 359 (04) :339-354
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