pH-responsive polymer-drug conjugates: Design and progress

被引：253

作者：

Pang, Xin ^{[1
]}

Jiang, Yue ^{[1
]}

Xiao, Qicai ^{[1
]}

Leung, Albert Wingnang ^{[1
]}

Hua, Heyu ^{[1
]}

Xu, Chuanshan ^{[1
]}

机构：

[1] Chinese Univ Hong Kong, Sch Chinese Med, Fac Med, Shatin, Hong Kong, Peoples R China

来源：

JOURNAL OF CONTROLLED RELEASE | 2016年 / 222卷

关键词：

pH-responsive; Polymer-drug conjugates; Drug delivery system; Tumor targeting; MESOPOROUS SILICA NANOPARTICLES; OVARIAN-CARCINOMA CELLS; IN-VITRO CYTOTOXICITY; HUMAN BREAST-CANCER; HPMA COPOLYMER; ANTICANCER DRUGS; CONTROLLED ACTIVATION; MULTIDRUG-RESISTANCE; ANTITUMOR EFFICACY; BOUND DOXORUBICIN;

D O I：

10.1016/j.jconrel.2015.12.024

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymer-drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, either in mildly acidic extracellular matrices of tumor tissues or, after cellular internalization, in acidic endosomes and lysosomes. As an emerging drug delivery system, such pH-responsive polymer-drug conjugates are able to selectively deliver and activate drug molecules while reducing their systemic side-effects. In this review, we present the recent advances in pH-responsive polymer-drug conjugates with different chemical structures and architectures, and attempt to clarify their mechanism of action, synthesis and characterization technology. Furthermore, several promising approaches for the future will also be suggested. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：116 / 129

页数：14

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