Synthesis of a new lactenediyne scaffold equipped with three handles

被引：16

作者：

Banfi, L ^{[1
]}

Guanti, G ^{[1
]}

机构：

[1] Dipartimento Chim & Chim Ind, I-16146 Genoa, Italy

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 41期

关键词：

D O I：

10.1016/S0040-4039(02)01603-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new lactenediyne scaffold endowed with three attachment points for substituents (handles) was synthesized. This scaffold was designed in order to be used to prepare libraries of compounds possessing a tethered nucleophile, an activating substituent, and DNA-complexing substructures. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：7427 / 7429

页数：3

相关论文

共 27 条

[1]

Banfi L, 1998, EUR J ORG CHEM, V1998, P1543

[2]

Banfi L, 2000, EUR J ORG CHEM, V2000, P939

[3] Intramolecular transamidation of β-lactams as a means for the enzymatic control of ring opening:: Effect of substituents on the rate of reaction [J].

Banfi, L ;

Guanti, G ;

Rasparini, M .

TETRAHEDRON LETTERS, 1998, 39 (51) :9539-9542

[4] Synthesis of a methoxy-substituted lactenediyne [J].

Banfi, L ;

Guanti, G .

TETRAHEDRON LETTERS, 2000, 41 (33) :6523-6526

[5] LACTENDIYNES - A NEW CLASS OF TRIGGERED CYCLIC ENEDIYNES [J].

BANFI, L ;

GUANTI, G .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1995, 34 (21) :2393-2395

[6] Rational design, synthesis, and reactivity of lactendiynes, a new class of cyclic enediynes ortho-fused with the beta-lactam ring [J].

Banfi, L ;

Basso, A ;

Guanti, G .

TETRAHEDRON, 1997, 53 (09) :3249-3268

[7]

BANFI L, 2002, IN PRESS EUR J ORG C

[8] A carbene insertion route to β-lactam fused cyclic enediynes [J].

Basak, A ;

Mandal, S .

TETRAHEDRON LETTERS, 2002, 43 (23) :4241-4243

[9] DNA-cleavage studies on N-substituted monocyclic enediynes:: Enhancement of potency by incorporation of intercalating or electron poor aromatic ring and subsequent design of a novel phototriggerable acyclic enediyne [J].

Basak, A ;

Bdour, HM ;

Shain, JC ;

Mandal, S ;

Rudra, KR ;

Nag, S .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2000, 10 (12) :1321-1325

[10] The synthesis and reactivity of novel azetidinyl enediynes [J].

Basak, A ;

Khamrai, UK ;

Mallik, U .

CHEMICAL COMMUNICATIONS, 1996, (06) :749-750