New nucleos(t)ide analogue monoprophylaxis after cessation of hepatitis B immunoglobulin is effective against hepatitis B recurrence

被引：45
作者：
Cholongitas, Evangelos [1 ]
Goulis, Ioannis [1 ]
Antoniadis, Nikolaos [2 ]
Fouzas, Ioannis [2 ]
Imvrios, George [2 ]
Papanikolaou, Vasilios [2 ]
Akriviadis, Evangelos [1 ]
机构：
[1] Aristotle Univ Thessaloniki, Hippokrat Gen Hosp Thessaloniki, Dept Internal Med 4, Sch Med, Thessaloniki 54642, Greece
[2] Aristotle Univ Thessaloniki, Dept Transplant Surg, GR-54006 Thessaloniki, Greece
来源：
TRANSPLANT INTERNATIONAL | 2014年 / 27卷 / 10期
关键词：
entecavir; glomerular filtration rate; hepatitis B recurrence; liver transplantation; renal function; tenofovir; POST-LIVER-TRANSPLANTATION; GLOMERULAR-FILTRATION-RATE; VIRUS RECURRENCE; IMMUNE GLOBULIN; HEPATOCELLULAR-CARCINOMA; LAMIVUDINE MONOTHERAPY; ANTIVIRAL THERAPY; RANDOMIZED-TRIAL; PROPHYLAXIS; INFECTION;
D O I：
10.1111/tri.12370
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
New nucleos(t)ide agents (NAs) [entecavir (ETV) and tenofovir (TDF)] have made hepatitis B immunoglobulin (HBIG)-sparing protocols an attractive approach against hepatitis B virus (HBV) recurrence after liver transplantation (LT). Twenty-eight patients transplanted for HBV cirrhosis in our centre were prospectively evaluated. After LT, each patient received HBIG (1000 IU IM/day for 7days and then monthly for 6months) plus ETV or TDF and then continued with ETV or TDF monoprophylaxis. All patients had undetectable HBV DNA at the time of LT, and they were followed up with laboratory tests including glomerular filtration rate (GFR) after LT. All patients (11 under ETV and 17 under TDF) remained HBsAg/HBV DNA negative during the follow-up period [median: 21 (range 9-43) months]. GFR was not different between TDF and ETV groups of patients at 6 and 12months and last follow-up (P value >0.05 for all comparisons). The two groups of patients were similar regarding their ratio of maximum rate of tubular phosphate reabsorption to the GFR (TmP/GFR). In conclusion, in this prospective study, we showed for the first time that maintenance therapy with ETV or TDF monoprophylaxis after 6months of low-dose HBIG plus ETV or TDF after LT is highly effective and safe.
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页码：1022 / 1028
页数：7
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