A-kinase anchoring proteins: protein kinase A and beyond

被引：170

作者：

Edwards, AS ^{[1
]}

Scott, JD ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Howard Hughes Med Inst, Vollum Inst, Portland, OR 97201 USA

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)00085-X

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of the functional consequences of PKA anchoring.

引用

页码：217 / 221

页数：5

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