共 49 条
Novel four-sided neural probe fabricated by a thermal lamination process of polymer films
被引:20
作者:
Shin, Soowon
[1
,2
]
Kim, Jae-Hyun
[3
]
Jeong, Joonsoo
[1
,2
]
Gwon, Tae Mok
[1
,2
]
Lee, Seung-Hee
[3
]
Kim, Sung June
[1
,2
]
机构:
[1] Seoul Natl Univ, Dept Elect & Comp Engn, Seoul 08826, South Korea
[2] Seoul Natl Univ, Inter Univ Semicond Res Ctr, Seoul, South Korea
[3] Korea Adv Inst Sci & Technol, Dept Biol Sci, Daejeon, South Korea
关键词:
Liquid crystal polymer (LCP);
Neural depth probe;
Polymer-based depth probe;
Three-dimensional neural probe;
LIQUID-CRYSTAL POLYMER;
ELECTRODE ARRAY;
MICROELECTRODE ARRAY;
DEPTH PROBE;
IMPLANTS;
INTERFACE;
SYSTEM;
LCP;
D O I:
10.1016/j.jneumeth.2016.12.017
中图分类号:
Q5 [生物化学];
学科分类号:
071010 ;
081704 ;
摘要:
Background: Ideally, neural probes should have channels with a three-dimensional (3-D) configuration to record the activities of 3-D neural circuits. Many types of 3-D neural probes have been developed; however, most of them were designed as an array of multiple shanks with electrodes located along one side of the shanks. New method: We developed a novel liquid crystal polymer (LCP)-based neural probe with four-sided electrodes. This probe has electrodes on four sides of the shank, i.e., the front, back and two sidewalls. To generate the proposed configuration of the electrodes, we used a thermal lamination process involving LCP films and laser micromachining. Results: The proposed novel four-sided neural probe, was used to successfully perform in vivo multichannel neural recording in the mouse primary somatosensory cortex. Comparison with existing method: The multichannel neural recording showed that the proposed four-sided neural probe can record spiking activities from a more diverse neuronal population than single-sided probes. This was confirmed by a pairwise Pearson correlation coefficient (Pearson's r) analysis and a cross-correlation analysis. Conclusion: The developed four-sided neural probe can be used to record various signals from a complex neural network. (C) 2016 Elsevier B.V. All rights reserved.
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页码:25 / 35
页数:11
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