Modulation of Excess Electron Transfer through LUMO Gradients in DNA Containing Phenanthrenyl Base Surrogates

被引：9

作者：

Roethlisberger, Pascal ^{[1
]}

Kaliginediand, Veerabhadrarao ^{[1
]}

Leumann, Christian J. ^{[1
]}

机构：

[1] Univ Bern, Dept Chem & Biochem, Freiestr 3, CH-3012 Bern, Switzerland

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 09期

基金：

瑞士国家科学基金会;

关键词：

electron transfer; oligonucleotides; phenanthrene; stacking interactions; CHARGE-TRANSPORT; INTERSTRAND-STACKING; TRANSFER EFFICIENCY; MITOCHONDRIAL-DNA; DERIVATIVES; SEQUENCE; THYMINE; DUPLEX; PAIR; ENHANCEMENT;

D O I：

10.1002/chem.201605846

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The modulation of excess electron transfer (EET) within DNA containing a dimethylaminopyrene (C-AP) as an electron donor and 5-bromouracil (BrdU) as an electron acceptor through phenanthrenyl pairs (phen-R) could be achieved by modifying the phenanthrenyl base surrogates with electron withdrawing and donating groups. Arranging the phenanthrenyl units to form a descending LUMO gradient increased the EET efficiency compared to the electron transfer through uniform LUMOs or an ascending LUMO gradient.

引用

页码：2022 / 2025

页数：4

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