Lipophagy: Selective Catabolism Designed for Lipids

被引：67

作者：

Weidberg, Hilla ^{[1
]}

Shvets, Elena ^{[1
]}

Elazar, Zvulun ^{[1
]}

机构：

[1] Weizmann Inst Sci, Dept Biol Chem, IL-76100 Rehovot, Israel

来源：

DEVELOPMENTAL CELL | 2009年 / 16卷 / 05期

关键词：

AUTOPHAGY;

D O I：

10.1016/j.devcel.2009.05.001

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Until recently, degradation of lipid droplets (LDs) has been thought to take place in the cytosol by resident lipases. In a recent issue of Nature, Singh and coworkers describe the involvement of selective autophagy in the delivery of lipid droplets for lysosomal degradation.

引用

页码：628 / 630

页数：3

共 9 条

[1] Autophagy counterbalances endoplasmic reticulum expansion during the unfolded protein response [J].

Bernales, Sebastian ;

McDonald, Kent L. ;

Walter, Peter .

PLOS BIOLOGY, 2006, 4 (12) :2311-2324

[2] PpAtg30 tags peroxisomes for turnover by selective autophagy [J].

Farre, Jean-Claude ;

Manjithaya, Ravi ;

Mathewson, Richard D. ;

Subramani, Suresh .

DEVELOPMENTAL CELL, 2008, 14 (03) :365-376

[3] A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates [J].

Kirkin, Vladimir ;

Lamark, Trond ;

Sou, Yu-Shin ;

Bjorkoy, Geir ;

Nunn, Jennifer L. ;

Bruun, Jack-Ansgar ;

Shvets, Elena ;

McEwan, David G. ;

Clausen, Terje H. ;

Wild, Philipp ;

Bilusic, Ivana ;

Theurillat, Jean-Philippe ;

Overvatn, Aud ;

Ishii, Tetsuro ;

Elazar, Zvulun ;

Komatsu, Masaaki ;

Dikic, Ivan ;

Johansen, Terje .

MOLECULAR CELL, 2009, 33 (04) :505-516

[4] Mature ribosomes are selectively degraded upon starvation by an autophagy pathway requiring the Ubp3p/Bre5p ubiquitin protease [J].

Kraft, Claudine ;

Deplazes, Anna ;

Sohrmann, Marc ;

Peter, Matthias .

NATURE CELL BIOLOGY, 2008, 10 (05) :602-610

[5] Autophagy fights disease through cellular self-digestion [J].

Mizushima, Noboru ;

Levine, Beth ;

Cuervo, Ana Maria ;

Klionsky, Danial J. .

NATURE, 2008, 451 (7182) :1069-1075

[6] The MAP1-LC3 conjugation system is involved in lipid droplet formation [J].

Shibata, Masahiro ;

Yoshimura, Kentaro ;

Furuya, Norihiko ;

Koike, Masato ;

Ueno, Takashi ;

Komatsu, Masaaki ;

Arai, Hiroyuki ;

Tanaka, Keiji ;

Kominami, Eiki ;

Uchiyama, Yasuo .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 382 (02) :419-423

[7]

SINGH R, 2009, NATURE IN PRESS, DOI DOI 10.1038/NATURE07976

[8] Cell biology of lipid droplets [J].

Thiele, Christoph ;

Spandl, Johanna .

CURRENT OPINION IN CELL BIOLOGY, 2008, 20 (04) :378-385

[9] Mitophagy [J].

Tolkovsky, Aviva M. .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2009, 1793 (09) :1508-1515

← 1 →