Creating a genetic risk score for coronary artery disease

被引：9

作者：

Dandona, Sonny ^{[1
]}

Roberts, Robert ^{[1
]}

机构：

[1] Univ Ottawa, Inst Heart, Ottawa, ON K1Y 4W7, Canada

来源：

CURRENT ATHEROSCLEROSIS REPORTS | 2009年 / 11卷 / 03期

关键词：

PREMATURE MYOCARDIAL-INFARCTION; LYMPHOTOXIN-ALPHA GENE; HEART-DISEASE; CHROMOSOME; 9P21.3; POLYMORPHISM; ASSOCIATION; POPULATION; VARIANTS; MEF2A; SUSCEPTIBILITY;

D O I：

10.1007/s11883-009-0028-4

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

Coronary artery disease (CAD) and its sequelae represent a significant health burden. Over the past two decades, numerous studies have attempted to link DNA sequence variation with the risk of CAD and related phenotypes. There has been significant evolution in technology from the early linkage studies within kindreds, and now we are able to use high-density genotyping to facilitate large-scale genome-wide association studies. The first novel genetic risk factor for CAD, 9p21.3, has been confirmed, and other loci are awaiting replication studies. The relative importance of each locus from a global standpoint and the incremental information conferred by testing for genetic variants remain to be determined.

引用

页码：175 / 181

页数：7

共 42 条

[1] Common polymorphisms of ALOX5 and ALOX5AP and risk of coronary artery disease [J].

Assimes, Themistocles L. ;

Knowles, Joshua W. ;

Priest, James R. ;

Basu, Analabha ;

Volcik, Kelly A. ;

Southwick, Audrey ;

Tabor, Holly K. ;

Hartiala, Jaana ;

Allayee, Hooman ;

Grove, Megan L. ;

Tabibiazar, Raymond ;

Sidney, Stephen ;

Fortmann, Stephen P. ;

Go, Alan ;

Hlatky, Mark ;

Iribarren, Carlos ;

Boerwinkle, Eric ;

Myers, Richard ;

Risch, Neil ;

Quertermous, Thomas .

HUMAN GENETICS, 2008, 123 (04) :399-408

[2] The molecular mechanism for the genetic disorder familial defective apolipoprotein B100 [J].

Borén, J ;

Ekström, U ;

Ågren, B ;

Nilsson-Ehle, P ;

Innerarity, TL .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (12) :9214-9218

[3] FAMILIAL HYPERCHOLESTEROLEMIA - DEFECTIVE BINDING OF LIPOPROTEINS TO CULTURED FIBROBLASTS ASSOCIATED WITH IMPAIRED REGULATION OF 3-HYDROXY-3-METHYLGLUTARYL COENZYME A REDUCTASE-ACTIVITY [J].

BROWN, MS ;

GOLDSTEIN, JL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1974, 71 (03) :788-792

[4]

Chan L., 1994, Cardiol Rev, V2, P130, DOI DOI 10.1097/00045415-199405000-00003

[5] Lymphotoxin-α gene and risk of myocardial infarction in 6,928 cases and 2,712 controls in the ISIS case-control study [J].

Clarke, Robert ;

Xu, Peng ;

Bennett, Derrick ;

Lewington, Sarah ;

Zondervan, Krina ;

Parish, Sarah ;

Palmer, Alison ;

Clark, Sarah ;

Cardon, Lon ;

Peto, Richard ;

Lathrop, Mark ;

Collins, Rory .

PLOS GENETICS, 2006, 2 (07) :990-996

[6] Sequence variations in PCSK9, low LDL, and protection against coronary heart disease [J].

Cohen, JC ;

Boerwinkle, E ;

Mosley, TH ;

Hobbs, HH .

NEW ENGLAND JOURNAL OF MEDICINE, 2006, 354 (12) :1264-1272

[7]

CUTLER D, 2007, EC BENEFITS HEART AT

[8] ALLELE-SPECIFIC INCREASE IN BASAL TRANSCRIPTION OF THE PLASMINOGEN-ACTIVATOR INHIBITOR-1 GENE IS ASSOCIATED WITH MYOCARDIAL-INFARCTION [J].

ERIKSSON, P ;

KALLIN, B ;

VANTHOOFT, FM ;

BAVENHOLM, P ;

HAMSTEN, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (06) :1851-1855

[9] Values for free/total prostate-specific antigen ratio as a function of age: necessity of reference validation in a Turkish population [J].

Mungan, A. Gorkem ;

Erol, Bulent ;

Akduman, Bulent ;

Bozdogan, Gurdal ;

Kiran, Sibel ;

Yesilli, Cetin ;

Mungan, N. Aydin .

CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2007, 45 (07) :912-916

[10] A variant of the gene encoding leukotriene A4 hydrolase confers ethnicity-specific risk of myocardial infarction [J].

Helgadottir, A ;

Manolescu, A ;

Helgason, A ;

Thorleifsson, G ;

Thorsteinsdottir, U ;

Gudbjartsson, DF ;

Gretarsdottir, S ;

Magnusson, KP ;

Gudmundsson, G ;

Hicks, A ;

Jonsson, T ;

Grant, SFA ;

Sainz, J ;

O'Brien, SJ ;

Sveinbjornsdottir, S ;

Valdimarsson, EM ;

Matthiasson, SE ;

Levey, AI ;

Abramson, JL ;

Reilly, MP ;

Vaccarino, V ;

Wolfe, ML ;

Gudnason, V ;

Quyyumi, AA ;

Topol, EJ ;

Rader, DJ ;

Thorgeirsson, G ;

Gulcher, JR ;

Hakonarson, H ;

Kong, A ;

Stefansson, K .

NATURE GENETICS, 2006, 38 (01) :68-74

← 1 2 3 4 5 →