Commentary: The Prospect of Cell-Based Therapy for Epilepsy

被引：6
作者：
Kriegstein, Arnold R. [1 ]
Pitkanen, Asla [2 ,3 ]
机构：
[1] Univ Calif San Francisco, Eli & Edythe Broad Ctr Regenerat Med & Stem Cell, Dept Neurol, San Francisco, CA 94143 USA
[2] Univ Kuopio, Epilepsy Res Lab, AI Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland
[3] Kuopio Univ Hosp, Dept Neurol, Kuopio 70211, Finland
来源：
NEUROTHERAPEUTICS | 2009年 / 6卷 / 02期
关键词：
Brain; disease modification; drug-refractory epilepsy; epileptogenesis; genetically-engineered cell lines; transplantation; TEMPORAL-LOBE EPILEPSY; SUPPRESS SEIZURE DEVELOPMENT; FETAL GABAERGIC NEURONS; KINDLING EPILEPTOGENESIS; INTERNEURON DEVELOPMENT; ADENOSINE KINASE; KAINIC ACID; RAT; TRANSPLANTS; GRAFTS;
D O I：
10.1016/j.nurt.2009.01.013
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
About 30% of patient with epilepsy do not respond to available antiepileptic drugs. In addition to seizure suppression, novel approaches are needed to prevent or alleviate epileptogenic process after various types of brain injuries. The use of cell transplants as factories to produce endogeneous anticonvulsants or as bricks to repair abnormal ictogenic and epileptogenic neuronal circuits has generated hope that cell-based therapies could become a novel therapeutic category in the treatment arsenal of epilepsy. Herein we summarize the current status and future perspectives of cell-based therapies in the treatment of epilepsy.
引用
收藏
页码：295 / 299
页数：5
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