DNA-based immunoassays for sensitive detection of protein

被引：8
作者：
Akter, Farhima [1 ]
Mie, Masayasu [1 ]
Kobatake, Eiry [1 ]
机构：
[1] Tokyo Inst Technol, Interdisciplinary Grad Sch Sci & Engn, Dept Environm Chem & Engn, Midori Ku, Yokohama, Kanagawa 2268502, Japan
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2014年 / 202卷
关键词：
Immunoassay; DNA-based immunoassay; IgG-binding protein; Protein-DNA conjugation; IGG-BINDING RECEPTORS; ANTIGEN-DETECTION; SMALL NUMBERS; PCR; EXPRESSION; ANTIBODIES; GENE; AMPLIFICATION; CONSTRUCTION; ASSAY;
D O I：
10.1016/j.snb.2014.05.135
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A new generation of immunoassays is being developed at a rapid pace for use as reliable, sensitive, specific detection of biological markers, both for diagnostic and therapeutic applications. DNA-based immunoassays have attracted increasing interest due to the ease by which nucleic acids can be synthesized and manipulated. This review summarizes the spectrum of DNA-modification techniques of specific antibodies and nucleic acid molecules, as well as different methodologies for signal amplification and read-out. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：1248 / 1256
页数：9
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