Stem Cell Therapy to Reduce Radiation-Induced Normal Tissue Damage

被引：42

作者：

Coppes, Rob P. ^{[1
,3
]}

van der Goot, Annemieke

Lombaert, Isabelle M. A. ^{[2
,4
]}

机构：

[1] Univ Groningen, Dept Cell Biol, Sect Radiat & Stress Cell Biol, NL-9700 AD Groningen, Netherlands

[2] Univ Groningen, Sect Stem Cells Biol, NL-9700 AD Groningen, Netherlands

[3] Univ Groningen, Univ Med Ctr Groningen, Dept Radiat Oncol, NL-9700 AD Groningen, Netherlands

[4] Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD USA

来源：

SEMINARS IN RADIATION ONCOLOGY | 2009年 / 19卷 / 02期

关键词：

MARROW-DERIVED CELLS; FUNCTIONAL MAMMARY-GLAND; LABEL-RETAINING CELLS; BONE-MARROW; PROGENITOR CELLS; MYOCARDIAL-INFARCTION; SALIVARY-GLANDS; SIDE POPULATION; SELF-RENEWAL; G-CSF;

D O I：

10.1016/j.semradonc.2008.11.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Normal tissue damage after radiotherapy is still a major problem in cancer treatment. Stem cell therapy may provide a means to reduce radiation-induced side effects and improve the quality of life of patients. This review discusses the current status in stem cell research with respect to their potential to reduce radiation toxicity. A number of different types of stem cells are being investigated for their potential to treat a variety of disorders. Their current status, localization, characterization, isolation, and potential in stem cell-based therapies are addressed. Although clinical adult stem cell research is still at an early stage, preclinical experiments show the potential these therapies may have. Based on the major advances made in this field, stem cell-based therapy has great potential to allow prevention or treatment of normal tissue damage after radiotherapy. Semin Radiat Oncol 19:112-121 (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：112 / 121

页数：10

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