Ex vivo lung perfusion

被引:70
作者
Machuca, Tiago N. [1 ]
Cypel, Marcelo [1 ]
机构
[1] Univ Toronto, Univ Hlth Network, Toronto Lung Transplant Program, Toronto, ON, Canada
关键词
Ex vivo lung perfusion (EVLP); lung transplantation; organ preservation; REJECTED DONOR LUNGS; CARDIAC-DEATH; CENTER EXPERIENCE; TRANSPLANTATION; HEART; DONATION; SMOKING; OUTCOMES; PRESERVATION;
D O I
10.3978/j.issn.2072-1439.2014.07.12
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Lung transplantation (LTx) is an established treatment option for eligible patients with end-stage lung disease. Nevertheless, the imbalance between suitable donor lungs available and the increasing number of patients considered for LTx reflects in considerable waitlist mortality. Among potential alternatives to address this issue, ex vivo lung perfusion (EVLP) has emerged as a modern preservation technique that allows for more accurate lung assessment and also improvement of lung function. Its application in high-risk donor lungs has been successful and resulted in safe expansion of the donor pool. This article will: (I) review the technical details of EVLP; (II) the rationale behind the method; (III) report the worldwide clinical experience with the EVLP, including the Toronto technique and others; (IV) finally, discuss the growing literature on EVLP application for donation after cardiac death (DCD) lungs.
引用
收藏
页码:1054 / 1062
页数:9
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