Selective transamidation of 3-oxo-N-acyl homoserine lactones by hydrazine derivatives

被引：1
作者：
Bertucci, Michael A. [1 ]
Lee, Stephen J. [2 ]
Gagne, Michel R. [1 ]
机构：
[1] Univ N Carolina, Dept Chem, Caudill & Kenan Labs, Chapel Hill, NC 27599 USA
[2] US Army Res Off, Res Triangle Pk, NC 27709 USA
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2014年 / 12卷 / 37期
关键词：
NUCLEOPHILIC CATALYSIS; QUORUM; OXIME; COMMUNICATION; HYDRAZONES; MECHANISM; LIGATION;
D O I：
10.1039/c4ob01156b
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A method for the selective transamidation of the 3-oxo sub-family of N-acyl homoserine lactones (3-oxo-AHLs) under physiologically relevant conditions has been developed. The reaction has the potential to serve as a strategy for selective knockdown of key autoinducers in a multicellular environment.
引用
收藏
页码：7197 / 7200
页数：4
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