Dibenzo-fused seven-membered nitrogen heterocycles by a tandem reduction-lactamization reaction

被引：41

作者：

Bunce, Richard A. ^{[1
]}

Schammerhorn, James E. ^{[1
]}

机构：

[1] Oklahoma State Univ, Dept Chem, Stillwater, OK 74078 USA

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 04期

关键词：

D O I：

10.1002/jhet.5570430432

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Efficient syntheses of dibenz[b,f][1,4]oxazepin-11(10H)-one, 5,10-dihydro-11H-dibenzo[b,e][1,4]diazepin-11-one and 5,11-dihydro-6H-dibenz[b,e]azepin-6-one are described using a tandem reduction-lactamization sequence. Precursors for these ring systems are available in 1-3 steps using nucleophilic aromatic substitution and Ullmann coupling methodology. Direct reduction-lactamization of these compounds using iron powder in acetic acid at 115 degrees affords the target heterocycles in >= 90% yield.

引用

页码：1031 / 1035

页数：5

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