Influence of stearic acid and beeswax as solid lipid matrix of lipid nanoparticles containing tacrolimus

被引：38

作者：

Dantas, Isabella Lima ^{[1
]}

Bastos, Kelven Tadeu S. ^{[1
]}

Machado, Micheline ^{[1
]}

Galvao, Juliana Gouveia ^{[1
]}

Lima, Alyne Dantas ^{[1
]}

Gonsalves, Joyce Kelly Marinheiro C. ^{[1
]}

Prado Almeida, Ellen Denise ^{[1
]}

Araujo, Adriano Antunes S. ^{[1
]}

de Meneses, Cristiano Teles ^{[3
]}

Sarmento, Victor Hugo V. ^{[2
]}

Nunes, Rogeria S. ^{[1
]}

Lira, Ana Amelia M. ^{[1
]}

机构：

[1] Univ Fed Sergipe, Dept Pharm, Ave Marechal Rondon S-N, BR-49100000 Sao Cristovao, SE, Brazil

[2] Univ Fed Sergipe, Dept Chem, BR-49500000 Itabaiana, SE, Brazil

[3] Univ Fed Sergipe, Dept Phys, BR-49500000 Itabaiana, SE, Brazil

来源：

JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY | 2018年 / 132卷 / 03期

关键词：

Lipid nanoparticles; Beeswax; Stearic acid; Tacrolimus; Atopic dermatitis; NANOLIPID CARRIER APPLICATION; SOLVENT DIFFUSION METHOD; ATOPIC-DERMATITIS; TOPICAL DELIVERY; DRUG-DELIVERY; THERMAL-ANALYSIS; AQUEOUS SYSTEM; DISPERSION; NLC; COMPATIBILITY;

D O I：

10.1007/s10973-018-7072-7

中图分类号：

O414.1 [热力学];

学科分类号：

摘要：

Lipid nanoparticles, both solid lipid nanoparticles and nanostructured lipid carriers (NLC), containing tacrolimus (FK) were obtained by solvent diffusion method associated with ultrasonication using stearic acid (SA) or beeswax as solid lipid. The oleic acid was used as liquid lipid in the NLC. Lipid nanoparticles were characterized by determining the drug loading, particle size, polydispersity index (PDI) and zeta potential (ZP). Analysis by differential scanning calorimetry and X-ray diffraction were performed. Lipid nanoparticles presented nano-sized from 139 to 275 nm. The PDI results show the particles present from 0.3 to 0.5, and ZP was higher than |25| mV. Drug loading ranged of 2.3-3.2%. SA nanoparticles presented better ZP, average size and distribution. However, beeswax nanoparticles showed higher drug loading. Results suggest there are no incompatibilities between FK and the raw materials. Polymorphic modifications were not observed. The results presented show that lipid nanoparticles using both lipids were successfully obtained and may represent promising delivery system of FK in topical formulations.

引用

页码：1557 / 1566

页数：10

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