The stem-cell niche as an entity of action

被引：1353

作者：

Scadden, DT ^{[1
]}

机构：

[1] Harvard Univ, Massachusetts Gen Hosp, Ctr Regenerat Med, Stem Cell Inst, Boston, MA 02114 USA

来源：

NATURE | 2006年 / 441卷 / 7097期

基金：

美国国家卫生研究院; 英国惠康基金;

关键词：

D O I：

10.1038/nature04957

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Stem-cell populations are established in 'niches'-specific anatomic locations that regulate how they participate in tissue generation, maintenance and repair. The niche saves stem cells from depletion, while protecting the host from over-exuberant stem-cell proliferation. It constitutes a basic unit of tissue physiology, integrating signals that mediate the balanced response of stem cells to the needs of organisms. Yet the niche may also induce pathologies by imposing aberrant function on stem cells or other targets. The interplay between stem cells and their niche creates the dynamic system necessary for sustaining tissues, and for the ultimate design of stem-cell therapeutics.

引用

页码：1075 / 1079

页数：5

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