Sarcopenia as a comorbidity-independent predictor of survival following radical cystectomy for bladder cancer

被引:112
作者
Mayr, Roman [1 ]
Gierth, Michael [1 ]
Zeman, Florian [2 ]
Reiffen, Marieke [1 ]
Seeger, Philipp [3 ]
Wezel, Felix [4 ]
Pycha, Armin [5 ,6 ]
Comploj, Evi [5 ]
Bonatti, Matteo [7 ]
Ritter, Manuel [3 ]
van Rhijn, Bas W. G. [1 ,8 ]
Burger, Maximilian [1 ]
Bolenz, Christian [4 ]
Fritsche, Hans-Martin [1 ]
Martini, Thomas [4 ]
机构
[1] Univ Regensburg, St Josef Med Ctr, Dept Urol, Landshuter Str 65, D-93053 Regensburg, Germany
[2] Univ Med Ctr Regensburg, Ctr Clin Studies, Regensburg, Germany
[3] Heidelberg Univ, Mannheim Med Ctr, Dept Urol, Mannheim, Germany
[4] Ulm Univ, Med Ctr, Dept Urol, Ulm, Germany
[5] Cent Hosp Bolzano, Dept Urol, Bolzano, Italy
[6] Sigmund Freud Univ, Med Sch Vienna, Vienna, Austria
[7] Cent Hosp Bolzano, Dept Radiol, Bolzano, Italy
[8] Antoni van Leeuwenhoek Hosp, Netherlands Canc Inst, Dept Surg Oncol Urol, Amsterdam, Netherlands
关键词
Frailty; Skeletal muscle mass; Bladder cancer; Prognosis; Urinary bladder neoplasm; SKELETAL-MUSCLE INDEX; PROGNOSTIC-FACTOR; COMPLICATIONS; PERFORMANCE; MANAGEMENT; MORTALITY; CACHEXIA; AGE;
D O I
10.1002/jcsm.12279
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Background A multicentre study was conducted to investigate the impact of sarcopenia as an independent predictor of oncological outcome after radical cystectomy for bladder cancer. Methods In total, 500 patients with available digital computed tomography scans of the abdomen obtained within 90 days before surgery were identified. The lumbar skeletal muscle index was measured using pre-operative computed tomography. Cancer-specific survival (CSS) and overall survival (OS) were estimated using Kaplan-Meier curves. Predictors of CSS and OS were analysed by univariable and multivariable Cox regression models. Results Based on skeletal muscle index, 189 patients (37.8%) were classified as sarcopenic. Patients with sarcopenia were older compared with their counterparts (P=0.002), but both groups were comparable regarding to gender, comorbidity, tumor, node, metastasis (TNM) stage, and type of urinary diversion (all P>0.05). In total, 234 (46.8%) patients died, and of these, 145 (29.0%) died because of urothelial carcinoma of the bladder. Sarcopenic patients had significantly worse 5 year OS (38.3% vs. 50.5%; P=0.002) and 5 year CSS (49.5% vs. 62.3%; P=0.016) rates compared with patients without sarcopenia. Moreover, sarcopenia was associated independently with both increased all-cause mortality (hazard ratio, 1.43; 95% confidence interval 1.09-1.87; P=0.01) and increased cancer-specific mortality (hazard ratio, 1.42; 95% confidence interval, 1.00-2.02; P=0.048). Our results are limited by the lack of prospective frailty assessment. Conclusions Sarcopenia has been shown to be an independent predictor for OS and CSS in a large multicentre study with patients undergoing radical cystectomy for bladder cancer.
引用
收藏
页码:505 / 513
页数:9
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