Multicomponent Oxyalkylation of Styrenes Enabled by Hydrogen-Bond-Assisted Photoinduced Electron Transfer

被引：164

作者：

Tlahuext-Aca, Adrian ^{[1
]}

Garza-Sanchez, R. Aleyda ^{[1
]}

Glorius, Frank ^{[1
]}

机构：

[1] Westfal Wilhelms Univ Munster, NRW Grad Sch Chem, Inst Organ Chem, Correnstr 40, D-48149 Munster, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 13期

关键词：

alkyl radicals; decarboxylation; hydrogen bonding; oxyalkylation; photoredox catalysis; LIGHT PHOTOREDOX CATALYSIS; ARYL DIAZONIUM SALTS; ALPHA-AMINO-ACIDS; CARBOXYLIC-ACIDS; DECARBOXYLATIVE ALKYNYLATION; METAL-FREE; QUATERNARY CARBONS; ALKENES; RADICALS; REAGENTS;

D O I：

10.1002/anie.201700049

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Herein, we disclose a strategy for the activation of N-(acyloxy)phthalimides towards photoinduced electron transfer through hydrogen bonding. This activation mode enables efficient access to C(sp(3))-centered radicals upon decarboxylation from bench-stable and readily available substrates. Moreover, we demonstrate that the formed alkyl radicals can be successfully employed in a novel redox-neutral method for constructing sp(3)-sp(3) bonds across styrene moieties that gives straightforward access to complex alcohol and ether scaffolds.

引用

页码：3708 / 3711

页数：4

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