Dementia in Parkinson's disease

被引：113

作者：

Hanagasi, Hasmet A. ^{[1
]}

Tufekcioglu, Zeynep ^{[1
]}

Emre, Murat ^{[1
]}

机构：

[1] Istanbul Univ, Istanbul Fac Med, Dept Neurol, Behav Neurol & Movement Disorders Unit, TR-34390 Istanbul, Turkey

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 2017年 / 374卷

关键词：

Parkinson's disease; Dementia; Dementia with Lewy Bodies; Cholinesterase inhibitors; MILD COGNITIVE IMPAIRMENT; SOCIETY TASK-FORCE; WHITE-MATTER HYPERINTENSITIES; LEWY BODIES; ALPHA-SYNUCLEIN; DIAGNOSTIC-CRITERIA; MENTAL DYSFUNCTION; SYDNEY MULTICENTER; COHORT; RISK;

D O I：

10.1016/j.jns.2017.01.012

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Dementia can occur in a substantial number of patients with Parkinson's disease with a point prevalence close to 30%. The cognitive profile is characterized by predominant deficits in executive, visuospatial functions, attention and memory. Behavioral symptoms are frequent such as apathy, visual hallucinations and delusions. The most prominent associated pathology is Lewy body-type and biochemical deficit is cholinergic. Placebo-controlled randomized trials with cholinesterase inhibitors demonstrated modest but significant benefits in cognition, behavioral symptoms and global functions. (C) 2017 Elsevier B.V. All rights reserved.

引用

页码：26 / 31

页数：6

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