Analysis of Residual Furan in Human Blood Using Solid Phase Microextraction-Gas Chromatography/Mass Spectrometry (SPME-GC/MS)

被引:0
|
作者
Lee, Yun-Kyung [1 ]
Jung, Seung-Won [1 ]
Lee, Sung Joon [2 ]
Lee, Kwang-Geun [1 ]
机构
[1] Dongguk Univ, Dept Food Sci & Technol, Seoul 100715, South Korea
[2] Korea Univ, Div Food Sci, Coll Life Sci & Biotechnol, Inst Biomed Sci & Safety, Seoul 136713, South Korea
关键词
furan; human blood; solid phase microextraction (SPME); gas chromatography/mass spectrometry (GC/MS); REACTIVE METABOLITE; MASS-SPECTROMETRY; CELL-PROLIFERATION; HEADSPACE METHOD; FOODS; CHEMICALS; ADDUCTS; ASSAY; RATS; MICE;
D O I
暂无
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
For all accurate risk assessment of furan, a potential human carcinogen, levels must be determined ill human blood plasma using a simple and robust assay. Ill thiS study solid phase microextraction-gas chromatography/mass spectrometry (SPME-GC/MS) Was Used to analyze blood plasma levels of furan ill 100 healthy individuals Who consumed a normal diet. The subjects were 30 to 70 years of age and 51% were women. Ultimately, an analytical method was established tor analyzing furan in human blood. The limit of quantification (LOQ) and furan recovery rate in blood were 1.0 ppb arld 104%, respectively. Finally, furan was detected in 21 individuals (13 males, 8 females) with levels ranging up to 17.86 ppb (ng furan/g food).
引用
收藏
页码:379 / 383
页数:5
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