Progression of rheumatoid arthritis following bone marrow transplantation - A case report with a 13-year followup

被引：96
作者：
McKendry, RJR
Huebsch, L
Leclair, B
机构：
[1] UNIV OTTAWA,OTTAWA,ON,CANADA
[2] ROYAL CANADIAN MOUNTED POLICE,CENT FORENS LAB,OTTAWA,ON,CANADA
来源：
ARTHRITIS AND RHEUMATISM | 1996年 / 39卷 / 07期
关键词：
D O I：
10.1002/art.1780390727
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The progression of rheumatoid arthritis (RA) is documented in a patient receiving a sex-mismatched, allogeneic bone marrow transplant (BMT) for gold-induced marrow aplasia. DNA typing confirmed a high probability of a full donor engraftment (complete chimerism). Although the RA was in complete remission 2 years post-BMT, clinical, laboratory, histologic, and radiologic evidence of the recurrence of synovitis from 3-13 years post-BMT is presented, Implications of these observations for theories of the pathogenesis of RA and the future of immunotherapies are discussed.
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页码：1246 / 1253
页数：8
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