Punica granatum L. mesocarp suppresses advanced glycation end products (AGEs)- and H2O2-induced oxidative stress and pro-inflammatory biomarkers

被引：9
作者：
Ramlagan, Piteesha [1 ,2 ]
Rondeau, Philippe [3 ]
Planesse, Cynthia [3 ]
Neergheen-Bhujun, Vidushi S. [1 ,2 ]
Fawdar, Shameem [2 ]
Bourdon, Emmanuel [3 ]
Bahorun, Theeshan [2 ]
机构：
[1] Univ Mauritius, Fac Sci, Dept Hlth Sci, Reduit, Mauritius
[2] Univ Mauritius, AND1 Ctr Biomed & Biomat Res, MSIRI Bldg, Reduit, Mauritius
[3] Univ La Reunion, INSERM, UMR Diabet Atherothrombose Therapies Reunion Ocea, Plateforme CYROI, F-97490 St Clotilde, Reunion, France
来源：
JOURNAL OF FUNCTIONAL FOODS | 2017年 / 29卷
关键词：
AGEs; Antioxidants; Oxidative stress; Pomegranate; Preadipocytes; BOVINE SERUM-ALBUMIN; KAPPA-B; ANTIOXIDANT PROPERTIES; GENE-EXPRESSION; POMEGRANATE; CAPACITY; CELLS; PROLIFERATION; PREVENTION; EXTRACTS;
D O I：
10.1016/j.jff.2016.12.007
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
The protective potential of pomegranate (Punica granatum L.) mesocarp extract (PME) on a cell model mimicking diabetes-like oxidative stress exposed to advanced glycation end products (AGEs) and hydrogen peroxide (H2O2) was investigated. The polyphenolic antioxidant rich PME afforded protection to erythrocytes from AAPH radical-induced lysis and significantly reduced (P < 0.001) ROS production in 3T3-L1 preadipocytes by preventing AGEs-modulated decrease in intrinsic antioxidant enzymatic activities and by reducing NOX1 expression. PME significantly inhibited protein carbonyl and AOPP levels following their increase in the presence of AGEs and H2O2 (P < 0.05). It exerted an anti-inflammatory effect on preadipocytes by suppressing IL-6 secretion. PME down-regulated the over-expression of pro-inflammatory mediators NF kappa B, iNOS and IL-6 post-AGEs treatment and concomitantly down-regulated the expression of AGEs receptor CD36 in the presence of AGEs. PME decreases oxidative stress and inflammation at adipose tissue level with the propensity to mitigate obesity-related disorders such as insulin resistance and type II diabetes. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：115 / 126
页数：12
相关论文
共 63 条
  • [21] THE DEOXYRIBOSE METHOD - A SIMPLE TEST-TUBE ASSAY FOR DETERMINATION OF RATE CONSTANTS FOR REACTIONS OF HYDROXYL RADICALS
    HALLIWELL, B
    GUTTERIDGE, JMC
    ARUOMA, OI
    [J]. ANALYTICAL BIOCHEMISTRY, 1987, 165 (01) : 215 - 219
  • [22] Improved detection of advanced oxidation protein products in plasma
    Hanasand, Marita
    Omdal, Roald
    Norheim, Katrine B.
    Goransson, Lasse G.
    Brede, Cato
    Jonsson, Grete
    [J]. CLINICA CHIMICA ACTA, 2012, 413 (9-10) : 901 - 906
  • [23] Inhibitory effect of phenolic acids on the proliferation of 3T3-L1 preadipocytes in relation to their antioxidant activity
    Hsu, Chin-Lin
    Huang, Shih-Li
    Yen, Gow-Chin
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2006, 54 (12) : 4191 - 4197
  • [24] High-throughput assay of oxygen radical absorbance capacity (ORAC) using a multichannel liquid handling system coupled with a microplate flourescence reader in 96-well format
    Huang, DJ
    Ou, BX
    Hampsch-Woodill, M
    Flanagan, JA
    Prior, RL
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (16) : 4437 - 4444
  • [25] Regulation of Btg2/TIS21/PC3 expression via reactive oxygen species-protein kinase C-NFκB pathway under stress conditions
    Imran, Muhammad
    Lim, In Kyoung
    [J]. CELLULAR SIGNALLING, 2013, 25 (12) : 2400 - 2412
  • [26] The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals
    Jia, Z
    Tang, MC
    Wu, JM
    [J]. FOOD CHEMISTRY, 1999, 64 (04) : 555 - 559
  • [27] Evaluation of antioxidant, antitumor and immunomodulatory properties of polysaccharide isolated from fruit rind of Punica granatum
    Joseph, Manu M.
    Aravind, S. R.
    Varghese, Sheeja
    Mini, S.
    Sreelekha, T. T.
    [J]. MOLECULAR MEDICINE REPORTS, 2012, 5 (02) : 489 - 496
  • [28] Jurenka J, 2008, ALTERN MED REV, V13, P128
  • [29] Study of Polyphenol Content and Antioxidant Capacity of Myrianthus Arboreus (Cecropiaceae) Root Bark Extracts
    Kasangana, Pierre Betu
    Haddad, Pierre Selim
    Stevanovic, Tatjana
    [J]. ANTIOXIDANTS, 2015, 4 (02): : 410 - 426
  • [30] Kaur S., 2011, AM J BIOMEDICAL SCI, V1, P177, DOI [10.5099/aj120200132, DOI 10.5099/AJ120200132]
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