Pimobendan improves right ventricular myocardial contraction and attenuates pulmonary arterial hypertension in rats with monocrotaline-induced pulmonary arterial hypertension

被引：11

作者：

Yoshiyuki, Rieko ^{[1
]}

Nakata, Telma Mary ^{[1
]}

Fukayama, Toshiharu ^{[1
]}

Hamabe, Lina ^{[1
]}

Huai-Che, Hsu ^{[1
]}

Suzuki, Shuji ^{[1
]}

Machida, Noboru ^{[2
]}

Fukushima, Ryuji ^{[1
]}

Tanaka, Ryou ^{[1
]}

机构：

[1] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Surg, Fuchu, Tokyo 1838509, Japan

[2] Tokyo Univ Agr & Technol, Fac Agr, Dept Vet Clin Oncol, Fuchu, Tokyo 1838509, Japan

来源：

JOURNAL OF MEDICAL ULTRASONICS | 2014年 / 41卷 / 02期

关键词：

Monocrotaline; Pimobendan; Pulmonary hypertension; Rat; Right ventricular hypertrophy; INHALED PROSTACYCLIN; PDE INHIBITORS; ECHOCARDIOGRAPHY; SILDENAFIL; SURVIVAL; THERAPY; CARDIOMYOPATHY; HEMODYNAMICS; EPOPROSTENOL; COMBINATION;

D O I：

10.1007/s10396-013-0488-6

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

The present study aimed to evaluate the therapeutic effect of pimobendan treatment for pulmonary hypertension (PH) in rats administered monocrotaline (MCT). Fifty-four 12-week-old male Sprague-Dawley rats were injected with monocrotaline or saline solution. Serial echocardiography and right ventricular systolic pressure (RVSP) measurement via a cardiac catheter were performed. After injection of MCT, rats received oral pimobendan (MCT/pimobendan group) or no treatment (MCT group) until undergoing echocardiography and cardiac catheter insertion. Right ventricular systolic pressure in the MCT/pimobendan group was lower than that in the MCT group at 6 weeks. Right ventricle free wall (RVFW) myocardial systolic velocity (Sm) in the MCT group showed a reduction compared with the saline group at 2 weeks. RVFW Sm in the MCT/pimobendan group was preserved as compared with the saline group at 2 weeks. RVFW Tei index in the MCT/pimobendan group showed a reduction compared with the saline group and the MCT group at 2 weeks. Echocardiography in the MCT/pimobendan group showed improvement compared with MCT rats. Both a reduction in RVSP and improvement in myocardial contraction were demonstrated with administration of pimobendan in rats with PH induced by MCT. Echocardiography evaluation of systolic function seems to be useful for monitoring excess administration of pimobendan.

引用

页码：173 / 180

页数：8

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