Potential neoplastic effects of parathion-methyl on rat liver

被引：15

作者：

Coral, M. Nisa Unaldi ^{[1
]}

Ucman, Sonay ^{[2
]}

Yildiz, Hasan ^{[2
]}

Oztas, Haydar ^{[3
]}

Dalkilic, Semih ^{[4
]}

机构：

[1] Mersin Univ, TR-33169 Mersin, Turkey

[2] Mustafa Kemal Univ, Arts & Sci Fac, Dept Biol, Antakya, Turkey

[3] Selcuk Univ, Educ Fac Biol, Educ Konya, Turkey

[4] Ankara Univ, Biotechnol Inst Ankara, TR-06100 Ankara, Turkey

来源：

JOURNAL OF ENVIRONMENTAL SCIENCES | 2009年 / 21卷 / 05期

关键词：

atypical acinar cell focuses; Ames test; carcinogenesis; parathion-methyl; MUTAGENICITY TEST; CELL FOCI; INSECTICIDES; METABOLITES; PESTICIDES; CANCER; HEALTH;

D O I：

10.1016/S1001-0742(08)62326-8

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term experiment with wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential carcinogenic.

引用

页码：696 / 699

页数：4

共 25 条

[1] Measurement of children's exposure to pesticides: Analysis of urinary metabolite levels in a probability-based sample [J].