Dimethyl fumarate: targeting glycolysis to treat MS

被引：21

作者：

Angiari, Stefano ^{[1
]}

O'Neill, Luke A. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Sch Biochem & Immunol, Trinity Biomed Sci Inst, Dublin 2, Ireland

来源：

CELL RESEARCH | 2018年 / 28卷 / 06期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/s41422-018-0045-3

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Dimethyl fumarate (DMF) is an immunomodulatory drug used in patients with multiple sclerosis (MS) and psoriasis. Kornberg and colleagues shed new light on DMF activity, demonstrating that it blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification of glyceraldehyde 3-phosphate dehydrogenase (GAPDH), which confirms the pro-inflammatory role of glycolysis and points to potential new targets to treat inflammatory diseases such as MS.

引用

页码：613 / 615

页数：3

共 10 条

[1] S-(2-succinyl)cysteine:: A novel chemical modification of tissue proteins by a Krebs cycle intermediate [J].

Alderson, Nathan L. ;

Wang, Yuping ;

Blatnik, Matthew ;

Frizzell, Norma ;

Walla, Michael D. ;

Lyons, Timothy J. ;

Alt, Nadja ;

Carson, James A. ;

Nagai, Ryji ;

Thorpe, Suzanne R. ;

Baynes, John W. .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 2006, 450 (01) :1-8

[2] Targeting Metabolism as a Novel Therapeutic Approach to Autoimmunity, Inflammation, and Transplantation [J].

Bettencourt, Ian A. ;

Powell, Jonathan D. .

JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :999-1005

[3] A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis [J].

Brueck, Juergen ;

Dringen, Ralf ;

Amasuno, Adriana ;

Pau-Charles, Ignasi ;

Ghoreschi, Kamran .

EXPERIMENTAL DERMATOLOGY, 2018, 27 (06) :611-624

[4] Dimethyl fumarate influences innate and adaptive immunity in multiple sclerosis [J].

Diebold, Martin ;

Sievers, Claudia ;

Bantug, Glenn ;

Sanderson, Nicholas ;

Kappos, Ludwig ;

Kuhle, Jens ;

Lindberg, Raija L. P. ;

Derfuss, Tobias .

JOURNAL OF AUTOIMMUNITY, 2018, 86 :39-50

[5] Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity [J].

Kornberg, Michael D. ;

Bhargava, Pavan ;

Kim, Paul M. ;

Putluri, Vasanta ;

Snowman, Adele M. ;

Putluri, Nagireddy ;

Calabresi, Peter A. ;

Snyder, Solomon H. .

SCIENCE, 2018, 360 (6387) :449-453

[6] THE SUCCINATED PROTEOME [J].

Merkley, Eric D. ;

Metz, Thomas O. ;

Smith, Richard D. ;

Baynes, John W. ;

Frizzell, Norma .

MASS SPECTROMETRY REVIEWS, 2014, 33 (02) :98-109

[7] Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis [J].

Mills, Elizabeth A. ;

Ogrodnik, Magdalena A. ;

Plave, Andrew ;

Mao-Draayer, Yang .

FRONTIERS IN NEUROLOGY, 2018, 9

[8] Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 [J].

Mills, Evanna L. ;

Ryan, Dylan G. ;

Prag, Hiran A. ;

Dikovskaya, Dina ;

Menon, Deepthi ;

Zaslona, Zbigniew ;

Jedrychowski, Mark P. ;

Costa, Ana S. H. ;

Higgins, Maureen ;

Hams, Emily ;

Szpyt, John ;

Runtsch, Marah C. ;

King, Martin S. ;

McGouran, Joanna F. ;

Fischer, Roman ;

Kessler, Benedikt M. ;

McGettrick, Anne F. ;

Hughes, Mark M. ;

Carroll, Richard G. ;

Booty, Lee M. ;

Knatko, Elena V. ;

Meakin, Paul J. ;

Ashford, Michael L. J. ;

Modis, Louise K. ;

Brunori, Gino ;

Sevin, Daniel C. ;

Fallon, Padraic G. ;

Caldwell, Stuart T. ;

Kunji, Edmund R. S. ;

Chouchani, Edward T. ;

Frezza, Christian ;

Dinkova-Kostova, Albena T. ;

Hartley, Richard C. ;

Murphy, Michael P. ;

O'Neill, Luke A. .

NATURE, 2018, 556 (7699) :113-+

[9] A guide to immunometabolism for immunologists [J].

O'Neill, Luke A. J. ;

Kishton, Rigel J. ;

Rathmell, Jeff .

NATURE REVIEWS IMMUNOLOGY, 2016, 16 (09) :553-565

[10] Identification of protein succination as a novel modification of tubulin [J].

Piroli, Gerardo G. ;

Manuel, Allison M. ;

Walla, Michael D. ;

Jepson, Matthew J. ;

Brock, Jonathan W. C. ;

Rajesh, Mathur P. ;

Tanis, Ross M. ;

Cotham, William E. ;

Frizzell, Norma .

BIOCHEMICAL JOURNAL, 2014, 462 :231-245

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