Regioselective α-arylation of coumarins and 2-pyridones with phenylhydrazines under transition-metal-free conditions

被引：56

作者：

Chauhan, Parul ^{[1
]}

Ravi, Makthala ^{[1
]}

Singh, Shikha ^{[1
]}

Prajapati, Prashant ^{[2
]}

Yadav, Prem P. ^{[1
]}

机构：

[1] CSIR Cent Drug Res Inst, Med & Proc Chem, Lucknow 226031, Uttar Pradesh, India

[2] Natl Inst Pharmaceut Educ & Res, Raebareli 229010, India

来源：

RSC ADVANCES | 2016年 / 6卷 / 01期

关键词：

CATALYZED DIRECT ARYLATION; OXIDATIVE ARYLATION; BOND FORMATION; ARYL IODIDES; ARENES; HETEROARENES; SERIES; ROUTE; FUNCTIONALIZATION; 3-PHENYLCOUMARINS;

D O I：

10.1039/c5ra20954d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A facile regioselective metal-free direct alpha-arylation of coumarins and 2-pyridones is achieved by the reaction of coumarins and 2-pyridones with phenylhydrazine in good yields. The reaction proceeds at room temperature under mild conditions using inexpensive reagents and without the need for step intensive activating groups. The methodology is operationally simple, practically viable and also allows the coupling of similar nitrogen heterocycle aza-coumarins without prerequisite N-protection.

引用

页码：109 / 118

页数：10

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