An Immunity-Associated lncRNA Signature for Predicting Prognosis in Gastric Adenocarcinoma

被引:3
作者
Zhao, Xiaowen [1 ,2 ]
Wu, Pingfan [1 ,2 ]
Liu, Dongling [1 ,3 ]
Li, Changtian [1 ]
Xue, Ling [1 ]
Liu, Zhe [1 ]
Zhu, Meng [1 ]
Yang, Jie [1 ]
Chen, Ziyi [1 ,2 ]
Li, Yaling [1 ,3 ]
She, Yali [1 ,3 ]
机构
[1] Gansu Univ Chinese Med, Sch Basic Med, Dept Pathol, Lanzhou, Gansu, Peoples R China
[2] 940th Hosp Joint Logist Support Force Chinese Peo, Lab Preclin Med, Key Lab Stem Cells & Gene Drug Gansu Prov, Lanzhou, Gansu, Peoples R China
[3] Gansu Univ Chinese Med, Prov Level Key Lab Mol Med Major Dis & Study Prev, Lanzhou, Gansu, Peoples R China
基金
中国国家自然科学基金;
关键词
LONG NONCODING RNAS; UP-REGULATION; CANCER; CELLS; IMMUNOTHERAPY; TUMORIGENESIS; PROGRESSION; EXPRESSION; RESISTANCE; TIM-3;
D O I
10.1155/2022/3035073
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Background. Gastric adenocarcinoma (GAD) is one of the most common tumors in the world and the prognosis is still very poor. Objective. We sought to identify reliable prognostic biomarkers for the progression of GAD and the sensitivity to drug therapy. Method. The RNA sequencing data of GAD was downloaded from the Cancer Genome Atlas (TCGA) database and used for analysis. Differentially expressed, immune-related lncRNA (DEIRlncRNA) was characterized by differential analysis and correlation analysis. Univariate Cox regression analysis was used to identify DEIRlncRNA associated with prognosis. Least absolute shrinkage and selection operator (LASSO) regression analysis allowed us to determine a signature composed of eight IRlncRNAs. Based on this signature, we further performed gene set enrichment analysis (GSEA) and somatic mutation analysis to evaluate the ability of this signature to predict prognosis. Results. In total, 72 immune-related lncRNAs (DEIRlncRNAs) with prognostic value were identified. These lncRNAs were used to construct a model containing eight immune-related lncRNAs (8-IRlncRNAs). Based on this risk model, we divided GAD patients into high-risk and low-risk groups. The analysis showed that the prognosis of the two groups was different and that the high-risk group had worse overall survival (OS). Immune cell infiltration analysis showed that the proportion of memory B cells increased in the high-risk group while the proportion of macrophages M1, T cells, CD4 memory-activated cells, and T cell follicular helpers decreased. GSEA results showed that 8-IRlncRNA was significantly enriched in tumorigenesis pathways such as myc. The results of somatic mutation analysis showed that the CDH1 gene was significantly mutated in the high-risk group. Conclusion. A prognostic signature of 8-IRlncRNAs in GAD was established and this signature was able to predict the prognosis of GAD patients.
引用
收藏
页数:13
相关论文
共 53 条
[1]   Survival Trends in Gastric Adenocarcinoma: A Population-Based Study in Sweden [J].
Asplund, Johannes ;
Kauppila, Joonas H. ;
Mattsson, Fredrik ;
Lagergren, Jesper .
ANNALS OF SURGICAL ONCOLOGY, 2018, 25 (09) :2693-2702
[2]   Comprehensive molecular characterization of gastric adenocarcinoma [J].
Bass, Adam J. ;
Thorsson, Vesteinn ;
Shmulevich, Ilya ;
Reynolds, Sheila M. ;
Miller, Michael ;
Bernard, Brady ;
Hinoue, Toshinori ;
Laird, Peter W. ;
Curtis, Christina ;
Shen, Hui ;
Weisenberger, Daniel J. ;
Schultz, Nikolaus ;
Shen, Ronglai ;
Weinhold, Nils ;
Keiser, David P. ;
Bowlby, Reanne ;
Sipahimalani, Payal ;
Cherniack, Andrew D. ;
Getz, Gad ;
Liu, Yingchun ;
Noble, Michael S. ;
Pedamallu, Chandra ;
Sougnez, Carrie ;
Taylor-Weiner, Amaro ;
Akbani, Rehan ;
Lee, Ju-Seog ;
Liu, Wenbin ;
Mills, Gordon B. ;
Yang, Da ;
Zhang, Wei ;
Pantazi, Angeliki ;
Parfenov, Michael ;
Gulley, Margaret ;
Piazuelo, M. Blanca ;
Schneider, Barbara G. ;
Kim, Jihun ;
Boussioutas, Alex ;
Sheth, Margi ;
Demchok, John A. ;
Rabkin, Charles S. ;
Willis, Joseph E. ;
Ng, Sam ;
Garman, Katherine ;
Beer, David G. ;
Pennathur, Arjun ;
Raphael, Benjamin J. ;
Wu, Hsin-Ta ;
Odze, Robert ;
Kim, Hark K. ;
Bowen, Jay .
NATURE, 2014, 513 (7517) :202-209
[3]   CDH1 Gene Mutation Hereditary Diffuse Gastric Cancer Outcomes: Analysis of a Large Cohort, Systematic Review of Endoscopic Surveillance, and Secondary Cancer Risk Postulation [J].
Benesch, Matthew G. K. ;
Bursey, Stuart R. ;
O'Connell, Andrew C. ;
Ryan, Morag G. ;
Howard, Carrie L. ;
Stockley, Cecily C. ;
Mathieson, Alexander .
CANCERS, 2021, 13 (11)
[4]  
Chen BB, 2018, METHODS MOL BIOL, V1711, P243, DOI 10.1007/978-1-4939-7493-1_12
[5]   Long non-coding RNAs in diseases related to inflammation and immunity [J].
Chen, Jiao ;
Ao, Liangfei ;
Yang, Jing .
ANNALS OF TRANSLATIONAL MEDICINE, 2019, 7 (18)
[6]   A phase 3 study of nivolumab in previously treated advanced gastric or gastroesophageal junction cancer (ATTRACTION-2): 2-year update data [J].
Chen, Li-Tzong ;
Satoh, Taroh ;
Ryu, Min-Hee ;
Chao, Yee ;
Kato, Ken ;
Chung, Hyun Cheol ;
Chen, Jen-Shi ;
Muro, Kei ;
Kang, Won Ki ;
Yeh, Kun-Huei ;
Yoshikawa, Takaki ;
Oh, Sang Cheul ;
Bai, Li-Yuan ;
Tamura, Takao ;
Lee, Keun-Wook ;
Hamamoto, Yasuo ;
Kim, Jong Gwang ;
Chin, Keisho ;
Oh, Do-Youn ;
Minashi, Keiko ;
Cho, Jae Yong ;
Tsuda, Masahiro ;
Sameshima, Hiroki ;
Kang, Yoon-Koo ;
Boku, Narikazu .
GASTRIC CANCER, 2020, 23 (03) :510-519
[7]   Gene regulation in the immune system by long noncoding RNAs [J].
Chen, Y. Grace ;
Satpathy, Ansuman T. ;
Chang, Howard Y. .
NATURE IMMUNOLOGY, 2017, 18 (09) :962-972
[8]  
Cheng G, 2015, INT J CLIN EXP PATHO, V8, P9452
[9]   Immunotherapy in advanced gastric cancer, is it the future? [J].
Coutzac, C. ;
Pernot, S. ;
Chaput, N. ;
Zaanan, A. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2019, 133 :25-32
[10]   Hereditary diffuse gastric cancer therapeutic roadmap: current and novel approaches in a nutshell [J].
El Rami, Fadi E. ;
Barsoumian, Hampartsoum B. ;
Khneizer, Gebran W. .
THERAPEUTIC ADVANCES IN MEDICAL ONCOLOGY, 2020, 12