Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis

被引：38

作者：

Cameron, Elizabeth M. ^{[1
]}

Spencer, Sade ^{[1
]}

Lazarini, Jonathan ^{[1
]}

Harp, Christopher T. ^{[1
]}

Ward, E. Sally ^{[2
]}

Burgoon, Mark ^{[3
]}

Owens, Gregory P. ^{[3
]}

Racke, Michael K. ^{[4
]}

Bennett, Jeffrey L. ^{[3
]}

Frohman, Elliot M. ^{[1
]}

Monson, Nancy L. ^{[1
,2
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Neurol, Dallas, TX 75154 USA

[2] Univ Texas SW Med Ctr Dallas, Dept Immunol, Dallas, TX 75154 USA

[3] Univ Colorado, Dept Neurol, Denver, CO 80262 USA

[4] Ohio State Univ, Med Ctr, Dept Neurol, Columbus, OH 43210 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 213卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

Multiple sclerosis; B lymphocytes; Antibodies; Gene rearrangement; Mutational signature; B-CELL RESPONSE; CEREBROSPINAL-FLUID; SOMATIC HYPERMUTATION; HUMAN-IMMUNOGLOBULIN; CLONAL EXPANSION; SELECTIVE INFLUENCES; DIAGNOSTIC-CRITERIA; PERIPHERAL-BLOOD; OPTIC NEURITIS; MRI CRITERIA;

D O I：

10.1016/j.jneuroim.2009.05.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：123 / 130

页数：8

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