Studies on electrochemical oxidation of azithromycin and its interaction with bovine serum albumin

被引：210

作者：

Wu, YH ^{[1
]}

Ji, XB ^{[1
]}

Hu, SS ^{[1
]}

机构：

[1] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China

来源：

BIOELECTROCHEMISTRY | 2004年 / 64卷 / 01期

基金：

中国国家自然科学基金;

关键词：

bovine serum albumin; azithromycin; multiwall carbon nanotube; electrochemistry; modified electrode;

D O I：

10.1016/j.bioelechem.2004.03.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel naroparticle film modified electrode has been constructed using a glassy carbon electrode (GCE) coated with a carbon nanotube-dihexadecylphosphate (DHP) film. This modified electrode exhibits an enhanced effectiveness for the oxidation of azithromycin. A method is also described for the evaluation of azithromycin-bovine serum albumin (BSA) interaction. The electrochemical behavior of azithromycin as well as its interaction with BSA at this nanoparticle film electrode has been investigated by cyclic voltammetry, linear sweep voltammetry, differential pulse voltammetry and chronocoulometry. The binding number and association constant between azithromycin and bovine serum albumin have been obtained. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：91 / 97

页数：7

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