The role of hydrogen sulfide in gastric mucosal damage

被引：25
|
作者：
Shen, Fang [1 ,2 ]
Zhao, Chong-Shun [1 ,2 ]
Shen, Mei-Fen [1 ]
Wang, Zhong [1 ,2 ]
Chen, Gang [1 ,2 ]
机构：
[1] Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou, Jiangsu, Peoples R China
[2] Soochow Univ, Affiliated Hosp 1, Brain & Nerve Res Lab, Suzhou, Jiangsu, Peoples R China
来源：
MEDICAL GAS RESEARCH | 2019年 / 9卷 / 02期
关键词：
hydrogen sulfide; gastric mucosa; experimental study; anti-oxidation; anti-inflammation; gastric mucosal blood flow; protective effects; nitric oxide; carbon monoxide; CARBON-MONOXIDE; OXIDATIVE STRESS; NITRIC-OXIDE; GASTROINTESTINAL-TRACT; PROTECTS MICE; BLOOD-FLOW; IN-VIVO; INJURY; INFLAMMATION; MECHANISM;
D O I：
10.4103/2045-9912.260650
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Gastrointestinal disease is a major global threat to public health. In the past few decades, numerous studies have focuses on the application of small molecule gases in the disease treatment. Increasing evidence has shown that hydrogen sulfide (H2S) has anti-inflammatory and anti-oxidative effects, and can regulate gastric mucosal blood flow in the gastric mucosa. After gastric mucosa damage, the level of H2S in the stomach decreases. Administration of H2S can protect and repair the damaged gastric mucosa. Therefore, H2S is a new target for the repair and treatment of gastric mucosa damage. In this review, we introduce the roles of H2S in the treatment of gastric mucosa damage and provide the potential strategies for further clinical treatment.
引用
收藏
页码：88 / 92
页数：5
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