Multisystem Inflammatory Syndrome in Children, the Real Disease of COVID-19 in Pediatrics - A Multicenter Case Series From Al-Ahsa, Saudi Arabia

被引:22
作者
Almoosa, Zainab A. [1 ]
Al Ameer, Heba H. [2 ]
AlKadhem, Sajjad M. [3 ]
Busaleh, Fadi [3 ]
AlMuhanna, Fatimah A. [3 ]
Kattih, Osama [4 ]
机构
[1] Almoosa Specialist Hosp, Pediat Infect Dis, Al Hufuf, Saudi Arabia
[2] Matern & Children Hosp, Infect Dis, Al Hasa, Saudi Arabia
[3] Matern & Children Hosp, Pediat, Al Hasa, Saudi Arabia
[4] Almoosa Specialist Hosp, Pediat Intens Care Unit, Al Hasa, Saudi Arabia
关键词
covid-19; msi-c; kawasaki; toxic shock syndrome;
D O I
10.7759/cureus.11064
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Fortunately, coronavirus disease 2019 (COVID-19) infection in pediatric populations exhibits a mild course of disease. However, a small number have recently been identified who develop a significant systemic inflammatory response, a new disease entity called multisystem inflammatory syndrome in children (MISC), especially after the peak of the wave in Al-Ahsa, Saudi Arabia, in early June to mid-July. In MIS-C children usually present a few days to a few weeks after recovery from COVID-19 with high grade fever, GI symptoms, Kawasaki-like picture or even toxic shock-like syndrome. Raising awareness about this disease entity is very fundamental to enable pediatricians and other health care providers to identify and manage these patients before it is too late. We describe 10 different cases of MIS-C with different risk factors and presentations.
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页数:10
相关论文
共 9 条
[1]   Lower reference limits of quantitative cord glucose-6-phosphate dehydrogenase estimated from healthy term neonates according to the clinical and laboratory standards institute guidelines: a cross sectional retrospective study [J].
Al-Abdi, Sameer Yaseen ;
Alsaigh, Amina Suleman ;
Aldawoud, Fahima Lugman ;
Al Sadiq, Amal Ali .
BMC PEDIATRICS, 2013, 13
[2]  
[Anonymous], 2020, PEDIAT MULTISYSTEM I
[3]  
[Anonymous], 2020, MULTISYSTEM INFLAMMA
[4]   Multisystem Inflammatory Syndrome in Children in New York State [J].
Dufort, Elizabeth M. ;
Koumans, Emilia H. ;
Chow, Eric J. ;
Rosenthal, Elizabeth M. ;
Muse, Alison ;
Rowlands, Jemma ;
Barranco, Meredith A. ;
Maxted, Angela M. ;
Rosenberg, Eli S. ;
Easton, Delia ;
Udo, Tomoko ;
Kumar, Jessica ;
Pulver, Wendy ;
Smith, Lou ;
Hutton, Brad ;
Blog, Debra ;
Zucker, Howard .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) :347-358
[5]   Multisystem Inflammatory Syndrome in US Children and Adolescents [J].
Feldstein, Leora R. ;
Rose, Erica B. ;
Horwitz, Steven M. ;
Collins, Jennifer P. ;
Newhams, Margaret M. ;
Son, Mary Beth F. ;
Newburger, Jane W. ;
Kleinman, Lawrence C. ;
Heidemann, Sabrina M. ;
Martin, Amarilis A. ;
Singh, Aalok R. ;
Li, Simon ;
Tarquinio, Keiko M. ;
Jaggi, Preeti ;
Oster, Matthew E. ;
Zackai, Sheemon P. ;
Gillen, Jennifer ;
Ratner, Adam J. ;
Walsh, Rowan F. ;
Fitzgerald, Julie C. ;
Keenaghan, Michael A. ;
Alharash, Hussam ;
Doymaz, Sule ;
Clouser, Katharine N. ;
Giuliano, John S. ;
Gupta, Anjali ;
Parker, Robert M. ;
Maddux, Aline B. ;
Havalad, Vinod ;
Ramsingh, Stacy ;
Bukulmez, Hulya ;
Bradford, Tamara T. ;
Smith, Lincoln S. ;
Tenforde, Mark W. ;
Carroll, Christopher L. ;
Riggs, Becky J. ;
Gertz, Shira J. ;
Daube, Ariel ;
Lansell, Amanda ;
Coronado Munoz, Alvaro ;
Hobbs, Charlotte V. ;
Marohn, Kimberly L. ;
Halasa, Natasha B. ;
Patel, Manish M. ;
Randolph, Adrienne G. .
NEW ENGLAND JOURNAL OF MEDICINE, 2020, 383 (04) :334-346
[6]   Hyperinflammatory shock in children during COVID-19 pandemic [J].
Riphagen, Shelley ;
Gomez, Xabier ;
Gonzalez-Martinez, Carmen ;
Wilkinson, Nick ;
Theocharis, Paraskevi .
LANCET, 2020, 395 (10237) :1607-1608
[7]   Brief Review on COVID-19: The 2020 Pandemic Caused by SARS-CoV-2 [J].
Valencia, Damian N. .
CUREUS JOURNAL OF MEDICAL SCIENCE, 2020, 12 (03)
[8]   Clinical Characteristics of 58 Children With a Pediatric Inflammatory Multisystem Syndrome Temporally Associated With SARS-CoV-2 [J].
Whittaker, Elizabeth ;
Bamford, Alasdair ;
Kenny, Julia ;
Kaforou, Myrsini ;
Jones, Christine E. ;
Shah, Priyen ;
Ramnarayan, Padmanabhan ;
Fraisse, Alain ;
Miller, Owen ;
Davies, Patrick ;
Kucera, Filip ;
Brierley, Joe ;
McDougall, Marilyn ;
Carter, Michael ;
Tremoulet, Adriana ;
Shimizu, Chisato ;
Herberg, Jethro ;
Burns, Jane C. ;
Lyall, Hermione ;
Levin, Michael .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2020, 324 (03) :259-269
[9]   Glucose-6-phosphate dehydrogenase deficiency enhances human coronavirus 229E infection [J].
Wu, Yi-Hsuan ;
Tseng, Ching-Ping ;
Cheng, Mei-Ling ;
Ho, Hung-Yao ;
Shih, Shin-Ru ;
Chiu, Daniel Tsun-Yee .
JOURNAL OF INFECTIOUS DISEASES, 2008, 197 (06) :812-816