Studies of interleukin-12 in chronic hepatitis B virus infection

被引：10
作者：
Naoumov, NV [1 ]
Rossol, S [1 ]
机构：
[1] UNIV HEIDELBERG, DEPT GASTROENTEROL, D-6800 MANNHEIM, GERMANY
来源：
JOURNAL OF VIRAL HEPATITIS | 1997年 / 4卷
关键词：
interleukin-12; TH1/TH2; cells; hepatitis B virus clearance; chronic hepatitis B; cytokines;
D O I：
10.1111/j.1365-2893.1997.tb00185.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Interleukin-12 is produced by antigen-presenting cells and regulates the balance between TH1/TH2, lymphocyte subsets, promoting cell-mediated immune reactions. Amongst patients with chronic hepatitis B undergoing interferon-alpha treatment, only those who clear hepatitis B virus show a substantial increase in the production of biologically active IL-12 and an inverse ratio between serum levels of IL-12p40 subunit and IL-12, The peak of serum IL-12, occurs after the hepatitis flare and precedes or coincides with the time of HBe seroconversion, These data indicate that IL-12 is an important element for establishing the host immune control on hepatitis B virus replication in patients with chronic hepatitis B virus infection.
引用
收藏
页码：87 / 91
页数：5
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