Serum levels of thrombotic markers in patients with acute myocardial infarction

被引：0
作者：
Islam, Shafiqul [1 ]
Yakout, Sobhy M. [2 ]
Al Daghri, Nasser M. [1 ,2 ]
Alhomida, Abdullah S. [1 ]
Khan, Haseeb A. [1 ]
机构：
[1] King Saud Univ, Coll Sci, Dept Biochem, Riyadh 11451, Saudi Arabia
[2] King Saud Univ, Coll Sci, Dept Biochem, Biomarkers Res Lab, Riyadh 11451, Saudi Arabia
来源：
INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE | 2014年 / 7卷 / 04期
关键词：
Acute myocardial infarction; thrombotic markers; TPA; PAI-1; PLASMINOGEN-ACTIVATOR INHIBITOR-1; C-REACTIVE PROTEIN; CREATINE-KINASE; MORTALITY; ADMISSION; CARNITINE; THERAPY; COUNTS; PAI-1; RISK;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Tissue plasminogen activator (TPA) and plasminogen activator inhibitor-1 (PAI-1) have pro-and anti-fibrinolytic activities respectively. The net fibrinolytic activity is mainly determined by the balance between TPA and PAI-1 levels. Considering the important role of these markers in thrombotic pathway, we determined the levels of TPA and PAI-1 in sera of 50 AMI patients, 100 patients with associated risk factors (dyslipidemia and high blood pressure) and 100 healthy controls. The findings showed significantly high levels of TPA and PAI-1 in AMI patients as compared to control subjects. Both these markers were only non-significantly increased in the risk group. There was no correlation between body mass index and these markers however TPA and PAI-1 were significantly correlated with age and systolic blood pressure, respectively. In conclusion, a combination of these markers could provide a useful tool to assess the prognosis of AMI.
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页码：1059 / 1063
页数：5
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