A biochemist's view of long-term potentiation

被引：98

作者：

Roberson, ED ^{[1
]}

English, JD ^{[1
]}

Sweatt, JD ^{[1
]}

机构：

[1] BAYLOR COLL MED, DIV NEUROSCI, HOUSTON, TX 77030 USA

来源：

LEARNING & MEMORY | 1996年 / 3卷 / 01期

关键词：

D O I：

10.1101/lm.3.1.1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review surveys the molecular mechanisms of long-term potentiation (LTP) from the point of view of a biochemist. On the basis of available data, LTP in area CA1 of the hippocampus is divided into three phases-initial, early, and late-and the mechanisms contributing to the induction and expression of each phase are examined. We focus on evidence for the involvement of various second messengers and their effecters as well as the biochemical strategies employed in each phase to convert a transient signal into a lasting change in the neuron. We also consider, from a biochemical perspective, the implications of a multiphase model for LTP.

引用

页码：1 / 24

页数：24

共 163 条

[1] MODIFIED HIPPOCAMPAL LONG-TERM POTENTIATION IN PKC-GAMMA-MUTANT MICE [J].