Signaling Pathways in the Specification of Arteries and Veins

被引：81

作者：

Corada, Monica ^{[1
]}

Morini, Marco Francesco ^{[1
]}

Dejana, Elisabetta ^{[1
,2
]}

机构：

[1] FIRC Inst Mol Oncol, IFOM, I-20139 Milan, Italy

[2] Univ Milan, Dept Biosci, Milan, Italy

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2014年 / 34卷 / 11期

基金：

欧洲研究理事会;

关键词：

endothelial cells; ENDOTHELIAL-CELL DIFFERENTIATION; GENOME-WIDE ASSOCIATION; RECEPTOR COUP-TFII; VENOUS DIFFERENTIATION; TRANSCRIPTIONAL REGULATION; INTRACRANIAL ANEURYSM; MOLECULAR-MECHANISMS; REDUNDANT ROLES; GENE-EXPRESSION; SONIC-HEDGEHOG;

D O I：

10.1161/ATVBAHA.114.303218

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The establishment of arterial and venous identity of endothelial cells is critical for the proper anatomic configuration and function of the vascular tree. Arterial and venous specification of endothelial cells is determined by genetic factors, although surrounding cells and hemodynamic forces may also contribute to vascular remodeling. This review provides an overview of the signaling pathways and related transcription factors implicated in differentiation of endothelial cells. We will discuss, in particular, the role of upstream and downstream effectors of Wnt, Sox, and Notch pathways. The understanding of the molecular mechanisms that orchestrate endothelial differentiation may have therapeutic relevance for diseases such as atherosclerosis, arteriovenous malformations, aneurysms, and others.

引用

页码：2372 / 2377

页数：6

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