Cerebral Vasospasm

被引：45

作者：

Baggott, Christopher D. ^{[1
]}

Aagaard-Kienitz, Beverley ^{[2
]}

机构：

[1] Univ Wisconsin Hosp & Clin, Dept Neurol Surg, Madison, WI 53792 USA

[2] Univ Wisconsin Hosp & Clin, Neuroendovasc Sect, Madison, WI 53792 USA

来源：

NEUROSURGERY CLINICS OF NORTH AMERICA | 2014年 / 25卷 / 03期

关键词：

Cerebral vasospasm; Subarachnoid hemorrhage; Neurologic deficits; Delayed ischemic neurologic injury; ANEURYSMAL SUBARACHNOID HEMORRHAGE; TRANSCRANIAL DOPPLER ULTRASONOGRAPHY; TRANSLUMINAL BALLOON ANGIOPLASTY; INTRAARTERIAL PAPAVERINE INFUSION; ENDOTHELIN RECEPTOR ANTAGONIST; TISSUE PLASMINOGEN-ACTIVATOR; CORTICAL SPREADING ISCHEMIA; OXIDE SYNTHASE GENE; BLOOD-FLOW; DOUBLE-BLIND;

D O I：

10.1016/j.nec.2014.04.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Cerebral vasospasm causes delayed ischemic neurologic deficits after aneurysmal subarachnoid hemorrhage. This is a well-established clinical entity with significant associated morbidity and mortality. The underlying patholphysiology is highly complex and poorly understood. Large-vessel vasospasm, autoregulatory dysfunction, inflammation, genetic predispositions, microcirculatory failure, and spreading cortical depolarization are aspects of delayed neurologic deterioration that have been described in the literature. This article presents a perspective on cerebral vasospasm, as guided by the literature to date, specifically examining the mechanism, diagnosis, and treatment of cerebral vasospasm.

引用

页码：497 / +

页数：33

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