Vascular Response to Drug-Eluting Stent With Biodegradable vs. Durable Polymer - Optical Coherence Tomography Substudy of the NEXT

被引：38

作者：

Kubo, Takashi ^{[1
]}

Akasaka, Takashi ^{[1
]}

Kozuma, Ken ^{[2
]}

Kimura, Kazuo ^{[3
]}

Fusazaki, Tetsuya ^{[4
]}

Okura, Hiroyuki ^{[5
]}

Shinke, Toshiro ^{[6
]}

Ino, Yasushi ^{[1
]}

Hasegawa, Takao ^{[7
]}

Takashima, Hiroaki ^{[8
]}

Takamisawa, Itaru ^{[9
]}

Yamaguchi, Hiroshi ^{[10
]}

Igarashi, Keiichi ^{[11
]}

Kadota, Kazushige ^{[12
]}

Tanabe, Kengo ^{[13
]}

Nakagawa, Yoshihisa ^{[14
]}

Muramatsu, Toshiya ^{[15
]}

Morino, Yoshihiro ^{[4
]}

Kimura, Takeshi ^{[16
]}

机构：

[1] Wakayama Med Univ, Dept Cardiovasc Med, Wakayama 6418510, Japan

[2] Teikyo Univ Hosp, Div Cardiol, Tokyo, Japan

[3] Yokohama City Univ, Div Cardiol, Med Ctr, Yokohama, Kanagawa 232, Japan

[4] Iwate Med Univ, Div Cardiol, Morioka, Iwate 020, Japan

[5] Kawasaki Med Sch, Div Cardiol, Kurashiki, Okayama, Japan

[6] Kobe Univ, Grad Sch Med, Div Cardiovasc Med, Kobe, Hyogo 657, Japan

[7] Osaka City Univ Hosp, Div Cardiovasc Med, Osaka, Japan

[8] Aichi Med Univ Hosp, Dept Cardiol, Nagakute, Aichi, Japan

[9] Sakakibara Mem Hosp, Div Cardiol, Tokyo, Japan

[10] Tenyoukai Cent Hosp, Div Cardiol, Kagoshima, Japan

[11] Hokkaido Social Insurance Hosp, Div Cardiol, Sapporo, Hokkaido, Japan

[12] Kurashiki Cent Hosp, Div Cardiol, Kurashiki, Okayama, Japan

[13] Mitsui Mem Hosp, Div Cardiol, Tokyo 101, Japan

[14] Tenri Hosp, Div Cardiol, Tenri, Nara 632, Japan

[15] Saiseikai Yokohamashi Tobu Hosp, Div Cardiol, Yokohama, Kanagawa, Japan

[16] Kyoto Univ, Grad Sch Med, Dept Cardiovasc Med, Kyoto, Japan

来源：

CIRCULATION JOURNAL | 2014年 / 78卷 / 10期

关键词：

Drug-eluting stent; Optical coherence tomography; Percutaneous coronary intervention; CORONARY-ARTERY; FOLLOW-UP; EVEROLIMUS; THROMBOSIS; OUTCOMES; LEADERS;

D O I：

10.1253/circj.CJ-14-0337

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background: The aim of the present study was to compare vascular healing response between everolimus-eluting stent (EES) and biolimus-eluting stent (BES) using optical coherence tomography (OCT). Methods and Results: In the NOBORI Biolimus-Eluting Versus XIENCE V/PROMUS Everolimus-Eluting Stent Trial (NEXT), a formal OCT substudy investigated 91 patients (55 EES-treated lesions in 48 patients and 51 BES-treated lesions in 43 patients) with 8-12 months follow-up imaging at 18 centers. A total of 980 frames with 8,996 struts in EES and 907 frames with 8,745 struts in BES were analyzed. Mean neointima thickness in EES and BES was 105 +/- 82 mu m and 91 +/- 80 mu m, respectively (P<0.001). With regard to stent-treated lesions, the percentage of struts not covered by neointima (3 +/- 7% vs. 9 +/- 10%, P<0.001) and the frequency of stent-treated lesions with any uncovered struts (n=28, 51% vs. n=42, 82%; P<0.001) were significantly lower in EES compared with BES. In addition, the percentage of malapposed struts (0.2 +/- 0.8% vs. 1.3 +/- 2.8%, P=0.006) and the frequency of stent-treated lesions with any malapposed struts (n=6, 11% vs. n=14, 27%; P=0.028) were significantly lower in EES compared with BES. Conclusions: Incomplete vascular healing characterized by the presence of struts not covered by neointima and malapposed struts was less common in EES compared with BES.

引用

页码：2408 / 2414

页数：7

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