Microbiome and Gluten

被引:42
作者
Sanz, Yolanda [1 ]
机构
[1] Natl Res Council IATA CSIC, Inst Agrochem & Food Technol, Microbial Ecol Nutr & Hlth Res Unit, Valencia, Spain
关键词
Microbiome; Microbiota; Gluten; Celiac disease; Pathobionts; Bacteroides; Enterobacteriaceae; Bifidobacteria; Inflammation; CELIAC-DISEASE PATIENTS; INNATE IMMUNE-RESPONSE; REGULATORY T-CELLS; INTESTINAL MICROBIOTA; DUODENAL MICROBIOTA; GUT MICROBIOTA; BACTERIA POPULATIONS; CHILDREN; ACTIVATION; MUCOSA;
D O I
10.1159/000440991
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Celiac disease (CD) is a frequent chronic inflammatory enteropathy caused by gluten in genetically predisposed individuals that carry disease susceptibility genes (HLA-DQ2/8). These genes are present in about 30-40% of the general population, but only a small percentage of carriers develops CD. Gluten is the key environmental trigger of CD, but its intake does not fully explain disease onset; indeed, an increased number of cases experience gluten intolerance in late adulthood after many years of gluten exposure. Consequently, additional environmental factors seem to be involved in CD. Epidemiological studies indicate that common perinatal and early postnatal factors influence both CD risk and intestinal microbiota structure. Prospective studies in healthy infants at risk of developing CD also reveal that the HLA-DQ genotype, in conjunction with other environmental factors, influences the microbiota composition. Furthermore, CD patients have imbalances in the intestinal microbiota (dysbiosis), which are not fully normalized despite their adherence to a gluten-free diet. Therefore, it is hypothesized that the disease can promote dysbiosis that aggravates CD pathogenesis, and dysbiosis, in turn, can initiate and sustain inflammation through the expansion of proinflammatory pathobionts and decline of anti-inflammatory mutualistic bacteria. Studies in experimental models are also contributing to understand the role of intestinal bacteria and its interactions with a predisposed genotype in promoting CD. Advances in this area could aid in the development of microbiome-informed intervention strategies that optimize the partnership between the gut microbiota and host immunity for improving CD management. (C) 2015 S. Karger AG, Basel
引用
收藏
页码:28 / 41
页数:14
相关论文
共 50 条
[21]   A gluten metabolism study in healthy individuals shows the presence of faecal glutenasic activity [J].
Caminero, Alberto ;
Nistal, Esther ;
Arias, Laura ;
Vivas, Santiago ;
Comino, Isabel ;
Real, Ana ;
Sousa, Carolina ;
Ruiz de Morales, Jose M. ;
Ferrero, Miguel A. ;
Rodriguez-Aparicio, Leandro B. ;
Casqueiro, Javier .
EUROPEAN JOURNAL OF NUTRITION, 2012, 51 (03) :293-299
[22]   Functional intestinal microbiome, new frontiers in prebiotic design [J].
Candela, Marco ;
Maccaferri, Simone ;
Turroni, Silvia ;
Carnevali, Paola ;
Brigidi, Patrizia .
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2010, 140 (2-3) :93-101
[23]   Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases [J].
Hirschberg, Sarah ;
Gisevius, Barbara ;
Duscha, Alexander ;
Haghikia, Aiden .
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (12)
[24]   Microbiome in the Gut-Skin Axis in Atopic Dermatitis [J].
Lee, So-Yeon ;
Lee, Eun ;
Park, Yoon Mee ;
Hong, Soo-Jong .
ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, 2018, 10 (04) :354-362
[25]   Gluten-Free Diet Alters the Gut Microbiome in Women with Autoimmune Thyroiditis [J].
Rodziewicz, Aleksandra ;
Szewczyk, Adrian ;
Bryl, Ewa .
NUTRIENTS, 2024, 16 (05)
[26]   The Role of Infectious Mediators and Gut Microbiome in the Pathogenesis of Celiac Disease [J].
Nejad, Mohammad Rostami ;
Ishaq, Sauid ;
Al Dulaimi, David ;
Zali, Mohammad Reza ;
Rostami, Kamran .
ARCHIVES OF IRANIAN MEDICINE, 2015, 18 (04) :244-249
[27]   The microbiota and microbiome in pancreatic cancer: more influential than expected [J].
Wei, Miao-Yan ;
Shi, Si ;
Liang, Chen ;
Meng, Qing-Cai ;
Hua, Jie ;
Zhang, Yi-Yin ;
Liu, Jiang ;
Zhang, Bo ;
Xu, Jin ;
Yu, Xian-Jun .
MOLECULAR CANCER, 2019, 18 (1)
[28]   Navigating the gluten-free boom [J].
Gaesser, Glenn A. ;
Angadi, Siddhartha S. .
JAAPA-JOURNAL OF THE AMERICAN ACADEMY OF PHYSICIAN ASSISTANTS, 2015, 28 (08) :1-7
[29]   Gluten-degrading bacteria are present in the human small intestine of healthy volunteers and celiac patients [J].
Herran, Alexandra R. ;
Perez-Andres, Jenifer ;
Caminero, Alberto ;
Nistal, Esther ;
Vivas, Santiago ;
Ruiz de Morales, Jose Maria ;
Casqueiro, Javier .
RESEARCH IN MICROBIOLOGY, 2017, 168 (07) :673-684
[30]   The Microbiome and Eating Disorders [J].
Seitz, Jochen ;
Trinh, Stefanie ;
Herpertz-Dahlmann, Beate .
PSYCHIATRIC CLINICS OF NORTH AMERICA, 2019, 42 (01) :93-+