Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors

被引：94

作者：

Anton, Luis C. ^{[1
]}

Yewdell, Jonathan W. ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Consejo Super Invest Cient, Ctr Biol Mol Severo Ochoa, Madrid, Spain

[2] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2014年 / 95卷 / 04期

基金：

美国国家卫生研究院;

关键词：

antigen processing; cotranslational degradation; translation; ribosome; compartmentalization; nuclear translation; TRANSFER-RNA-SYNTHETASES; ACTIN MESSENGER-RNA; OPEN READING FRAME; PROTEIN-SYNTHESIS; NUCLEAR TRANSLATION; QUALITY-CONTROL; COTRANSLATIONAL UBIQUITINATION; SUBCELLULAR-DISTRIBUTION; ANTIGENIC PEPTIDES; LIVED PROTEINS;

D O I：

10.1189/jlb.1113599

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Review on the generation of antigenic peptides. MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.

引用

页码：551 / 562

页数：12

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