Translating DRiPs: MHC class I immunosurveillance of pathogens and tumors

被引：94

作者：

Anton, Luis C. ^{[1
]}

Yewdell, Jonathan W. ^{[2
]}

机构：

[1] Univ Autonoma Madrid, Consejo Super Invest Cient, Ctr Biol Mol Severo Ochoa, Madrid, Spain

[2] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2014年 / 95卷 / 04期

基金：

美国国家卫生研究院;

关键词：

antigen processing; cotranslational degradation; translation; ribosome; compartmentalization; nuclear translation; TRANSFER-RNA-SYNTHETASES; ACTIN MESSENGER-RNA; OPEN READING FRAME; PROTEIN-SYNTHESIS; NUCLEAR TRANSLATION; QUALITY-CONTROL; COTRANSLATIONAL UBIQUITINATION; SUBCELLULAR-DISTRIBUTION; ANTIGENIC PEPTIDES; LIVED PROTEINS;

D O I：

10.1189/jlb.1113599

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Review on the generation of antigenic peptides. MHC class I molecules display oligopeptides on the cell surface to enable T cell immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in detecting viruses, which can complete a full replication cycle in just hours, whereas tumor detection is typically a finding-the-needle-in-the-haystack exercise. We review current evidence supporting a nonrandom, compartmentalized selection of peptidogenic substrates that focuses on rapidly degraded translation products as a main source of peptide precursors to optimize immunosurveillance of pathogens and tumors.

引用

页码：551 / 562

页数：12

共 175 条

[1] Involvement of Bag6 and the TRC pathway in proteasome assembly [J].

Akahane, Takashi ;

Sahara, Kazutaka ;

Yashiroda, Hideki ;

Tanaka, Keiji ;

Murata, Shigeo .

NATURE COMMUNICATIONS, 2013, 4

[2] Visualization of the joining of ribosomal subunits reveals the presence of 80S ribosomes in the nucleus [J].

Al-Jubran, Khalid ;

Wen, Jikai ;

Abdullahi, Akilu ;

Chaudhury, Subhendu Roy ;

Li, Min ;

Ramanathan, Preethi ;

Matina, Annunziata ;

De, Sandip ;

Piechocki, Kim ;

Rugjee, Kushal Nivriti ;

Brogna, Saverio .

RNA, 2013, 19 (12) :1669-1683

[3] PROTEIN SYNTHESIS IN ISOLATED CELL NUCLEI [J].

ALLFREY, VG ;

MIRSKY, AE ;

OSAWA, S .

JOURNAL OF GENERAL PHYSIOLOGY, 1957, 40 (03) :451-490

[4] Translation of pre-spliced RNAs in the nuclear compartment generates peptides for the MHC class I pathway [J].

Apcher, Sebastien ;

Millot, Guy ;

Daskalogianni, Chrysoula ;

Scherl, Alexander ;

Manoury, Benedicte ;

Fahraeus, Robin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (44) :17951-17956

[5] Major source of antigenic peptides for the MHC class I pathway is produced during the pioneer round of mRNA translation [J].

Apcher, Sebastien ;

Daskalogianni, Chrysoula ;

Lejeune, Fabrice ;

Manoury, Benedicte ;

Imhoos, Gabriela ;

Heslop, Lea ;

Fahraeus, Robin .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (28) :11572-11577

[6] BINDING OF IMMUNOGENIC PEPTIDES TO IA HISTOCOMPATIBILITY MOLECULES [J].

BABBITT, BP ;

ALLEN, PM ;

MATSUEDA, G ;

HABER, E ;

UNANUE, ER .

NATURE, 1985, 317 (6035) :359-361

[7] A rapid, reversible, and tunable method to regulate protein function in living cells using synthetic small molecules [J].

Banaszynski, Laura A. ;

Chen, Lin-chun ;

Maynard-Smith, Lystranne A. ;

Ooi, A. G. Lisa ;

Wandless, Thomas J. .

CELL, 2006, 126 (05) :995-1004

[8] Understanding GFP posttranslational chemistry: Structures of designed variants that achieve backbone fragmentation, hydrolysis, and decarboxylation [J].

Barondeau, DP ;

Kassmann, CJ ;

Tainer, JA ;

Getzoff, ED .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2006, 128 (14) :4685-4693

[9] Soluble plasma HLA peptidome as a potential source for cancer biomarkers [J].

Bassani-Sternberg, Michal ;

Barnea, Eilon ;

Beer, Ilan ;

Avivi, Irit ;

Katz, Tami ;

Admon, Arie .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 107 (44) :18769-18776

[10] Specialized Yeast Ribosomes: A Customized Tool for Selective mRNA Translation [J].

Bauer, Johann W. ;

Brandl, Clemens ;

Haubenreisser, Olaf ;

Wimmer, Bjoern ;

Weber, Manuela ;

Karl, Thomas ;

Klausegger, Alfred ;

Breitenbach, Michael ;

Hintner, Helmut ;

von der Haar, Tobias ;

Tuite, Mick F. ;

Breitenbach-Koller, Lore .

PLOS ONE, 2013, 8 (07)

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