The C825T Polymorphism in the G-protein Beta 3 Subunit Gene in Chinese Patients with Preeclampsia

被引：6
作者：
He, Guolin [2 ]
Liu, Xinghui [2 ]
Fan, Ping [1 ]
Liu, Rui [3 ]
Huang, Yi [1 ]
Wang, Xiaosu [1 ]
Li, Qin [1 ]
Wu, Hongmei [1 ]
Liu, Yu [4 ]
Liu, Bingwen [4 ]
Bai, Huai [1 ]
机构：
[1] Sichuan Univ, W China Hosp 2, Unit Lab Med, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, W China Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, W China Hosp, Div Peptides Related Human Dis, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, W China Sch Preclin & Forens Med, Dept Biochem & Mol Biol, Chengdu 610041, Sichuan, Peoples R China
来源：
HYPERTENSION IN PREGNANCY | 2009年 / 28卷 / 02期
关键词：
Pregnancy induced hypertension; Preeclampsia; G-protein beta 3 subunit gene; Polymorphism; NECROSIS-FACTOR-ALPHA; BLOOD-PRESSURE; 825T ALLELE; ASSOCIATION; HYPERTENSION; GNB3; VARIANT; EXCRETION; PREGNANCY; ECLAMPSIA;
D O I：
10.1080/10641950802366245
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Objectives: The objective of the study was to investigate the relationship of a C825T polymorphism of the gene encoding the G protein 3 subunit with preeclampsia in a South-West Chinese population. Results: In the case-control study which included 221 preeclamptic case subjects and 277 normal control subjects the allele frequency of 825CT in the GNB3 gene was 47.29% in patients with preeclampsia and 49.28% in the control group. Furthermore, there was no significant association between the polymorphism and blood pressure levels in the case or control group. However, it showed that the TT homozygotes (n = 39) in obese patients had higher diastolic blood pressure levels than CC homozygotes (n = 47) or CT heterozygotes (n = 84) during pregnancy (p 0.05). Conclusion: Our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to preeclampsia in a South West Chinese population.
引用
收藏
页码：156 / 167
页数：12
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