Rational Design and Bioimaging Applications of Highly Selective Fluorescence Probes for Hydrogen Polysulfides

被引：196

作者：

Liu, Chunrong ^{[1
]}

Chen, Wei ^{[1
]}

Shi, Wen ^{[2
]}

Peng, Bo ^{[1
]}

Zhao, Yu ^{[1
]}

Ma, Huimin ^{[2
]}

Xian, Ming ^{[1
]}

机构：

[1] Washington State Univ, Dept Chem, Pullman, WA 99164 USA

[2] Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing 100190, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 20期

关键词：

SULFIDE; SULFUR; SULFHYDRATION; CHEMOSENSORS; CHEMISTRY; CYSTEINE; BIOLOGY;

D O I：

10.1021/ja502968x

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reactive sulfur species have received considerable attention due to their various biological functions. Among these molecules, hydrogen polysulfides (H2Sn, n > 1) are recently suggested to be the actual signaling molecules derived from hydrogen sulfide (H2S). Hydrogen polysulfides may also have their own biosynthetic pathways. The research on H2Sn is rapidly growing. However, the detection of H2Sn is still challenging. In this work we report a H2Sn-mediated benzodithiolone formation under mild conditions. Based on this reaction, specific fluorescent probes for H2Sn are prepared and evaluated. The probe DSP-3 shows good selectivity and sensitivity for H2Sn.

引用

页码：7257 / 7260

页数：4

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