Hematopoietic stem cell aging

被引：48
作者：
Geiger, Hartmut [1 ,2 ,3 ,4 ]
Denkinger, Michael [5 ]
Schirmbeck, Reinhold [6 ]
机构：
[1] Univ Ulm, Inst Mol Med Stem Cell & Aging, D-89069 Ulm, Germany
[2] Univ Ulm, Aging Res Ctr, D-89069 Ulm, Germany
[3] Cincinnati Childrens Hosp Med Ctr, Div Expt Hematol & Canc Biol, Cincinnati, OH 45229 USA
[4] Univ Cincinnati, Cincinnati, OH USA
[5] Univ Ulm, Geriatr Ctr, AGAPLESION Bethesda Clin, D-89069 Ulm, Germany
[6] Univ Hosp Ulm, Dept Internal Med 1, Ulm, Germany
来源：
CURRENT OPINION IN IMMUNOLOGY | 2014年 / 29卷
关键词：
AGE-RELATED-CHANGES; PROGENITOR CELLS; SUBTYPES; BIOLOGY; LEUKEMOGENESIS; DYSREGULATION; HETEROGENEITY; MOBILIZATION; COMPARTMENT; SENESCENCE;
D O I：
10.1016/j.coi.2014.05.002
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Aging is organized in a hierarchy, in which aging of cells results in aged tissues, ultimately limiting lifespan. For organ systems that also in the adult depend on stem cells for tissue homeostasis like the hematopoietic system that forms immune cells, it is believed that aging of the stem cells strongly contributes to aging-associated dysfunction. In this review, we summarize current aspects on cellular and molecular mechanisms that are associated with aging of hematopoietic stem cells, the role of the stem cell niche for stem cell aging as well as novel and encouraging experimental approaches to attenuate aging of hematopoietic stem cells to target immunosenescence.
引用
收藏
页码：86 / 92
页数：7
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