Antifouling Dendrimer-Entrapped Copper Sulfide Nanoparticles Enable Photoacoustic Imaging-Guided Targeted Combination Therapy of Tumors and Tumor Metastasis

被引：54

作者：

Ouyang, Zhijun ^{[1
]}

Li, Du ^{[1
]}

Xiong, Zhijuan ^{[1
]}

Song, Cong ^{[1
]}

Gao, Yue ^{[1
]}

Liu, Renna ^{[1
]}

Shen, Mingwu ^{[1
]}

Shi, Xiangyang ^{[1
]}

机构：

[1] Donghua Univ, Coll Chem Chem Engn & Biotechnol, State Key Lab Modificat Chem Fiber & Polymer Mat, Shanghai 201620, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2021年 / 13卷 / 05期

基金：

中国国家自然科学基金;

关键词：

dendrimers; copper sulfide nanoparticles; photoacoustic imaging; gene therapy; photothermal therapy; tumor metastasis inhibition;

D O I：

10.1021/acsami.0c21620

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

( )The development of functional intelligent theranostic nanoplatfonn for imaging-directed synchronous inhibition of primary tumor and tumor metastasis is still a challenging task. We present here the creation of functional dendrimer-entrapped CuS nanoparticles (CuS DENPs) complexed with plasmid DNA-encoding hypermethylation in cancer 1 (pDNA-HIC1) for photoacoustic (PA) imaging-directed simultaneous inhibition of tumors and tumor metastasis. Poly(amidoamine) dendrimers of generation 5 were covalently attached with 1,3-propane sultone and arginine-glycine-aspartic acid (RGD) peptide through a spacer of polyethylene glycol) and adopted for the templated synthesis of CuS NPs. The prepared functional RGD-CuS DENPs possess a mean CuS core diameter of 4.2 nm, good colloidal stability, and an excellent absorption feature in the second near-infrared window, thus having a photothermal conversion efficiency of 49.8% and an outstanding PA imaging capability. The functional DENPs can effectively deliver pDNA-HIC1 to prevent cancer cell invasion and metastasis in a serum-enhancing manner by virtue of zwitterionic modification-rendered antifouling property. The developed RGD-CuS DENPs/pDNA polyplexes display alpha(v)beta(3) integrin-targeted enhanced anticancer activity through the combined CuS NP-mediated photothermal therapy (PTT) and pDNA delivery-rendered cancer cell metastasis inhibition. This can also be proven by the therapeutic efficacy of a triple-negative breast cancer model in vivo, where inhibition of both the primary subcutaneous tumor and lung metastasis can be realized. The created dendrimer-CuS hybrid nanoplatform represents one of the updated designs of nanomedicine for PA imaging-directed combination PTT/gene therapy of tumors and tumor metastasis.

引用

页码：6069 / 6080

页数：12

共 52 条

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