Clinical characteristics, risk factors, and incidence of symptomatic coronavirus disease 2019 in a large cohort of adults living with HIV: a single-center, prospective observational study

被引：93

作者：

Inciarte, Alexy ^{[1
]}

Gonzalez-Cordon, Ana ^{[1
]}

Rojas, Jhon ^{[1
]}

Torres, Berta ^{[1
]}

de Lazzari, Elisa ^{[1
]}

de la Mora, Lorena ^{[1
]}

Martinez-Rebollar, Maria ^{[1
]}

Laguno, Montserrat ^{[1
]}

Callau, Pilar ^{[1
]}

Gonzalez-Navarro, Azucena ^{[3
]}

Leal, Lorna ^{[1
]}

Garcia, Felipe ^{[1
]}

Mallolas, Josep ^{[1
]}

Mosquera, Mar ^{[2
]}

Marcos, Maria A. ^{[2
]}

Ambrosioni, Juan ^{[1
]}

Miro, Josep M. ^{[1
]}

Martinez, Esteban ^{[1
]}

Blanco, Jose L. ^{[1
]}

机构：

[1] Univ Barcelona, Infect Dis Dept, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, C Villarroel 170, Barcelona 08036, Spain

[2] Univ Barcelona, Microbiol Dept, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

[3] Univ Barcelona, Immunol Dept, Hosp Clin Barcelona, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Barcelona, Spain

来源：

AIDS | 2020年 / 34卷 / 12期

关键词：

coronavirus disease 2019; HIV; prospective observational trial; severe acute respiratory syndrome coronavirus 2;

D O I：

10.1097/QAD.0000000000002643

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background: It is unclear how characteristics, risk factors, and incidence of coronavirus disease 2019 (COVID-19) in people living with HIV (PLWH) differ from the general population. Methods: Prospective observational single-center cohort study of adult PLWH reporting symptoms of COVID-19. We assessed clinical characteristics, risk factors for COVID-19 diagnosis and severity, and standardized incidence rate ratio for COVID-19 cases in PLWH cohort and in Barcelona. Results: From 1 March 2020 to 10 May 2020, 53 out of 5683 (0.9% confidence interval 0.7-1.2%) PLWH were diagnosed with COVID-19. Median age was 44 years, CD4(+) T cells were 618/mu l and CD4(+)/CD8(+) was 0.90. All but two individuals were virologically suppressed. Cough (87%) and fever (82%) were the most common symptoms. Twenty-six (49%) were admitted, six (14%) had severe disease, four (8%) required ICU admission, and two (4%) died. Several laboratory markers (lower O-2 saturation and platelets, and higher leukocytes, creatinine, lactate dehydrogenase, C reactive protein, procalcitonin, and ferritin) were associated with COVID-19 severity. No HIV or antiretroviral-related factors were associated with COVID-19 diagnosis or severity. Standardized incidence rate ratios of confirmed or confirmed/probable COVID-19 in PLWH were 38% (95% confidence interval 27-52%, P<0.0001) and 33% (95% confidence interval 21-50%, P<0.0001), respectively relative to the general population. Conclusion: PLWH with COVID-19 did not differ from the rest of the HIV cohort. Clinical presentation, severity rate, and mortality were not dependent on any HIV-related or antiretroviral-related factor. COVID-19 standardized incidence rate was lower in PLWH than in the general population. These findings should be confirmed in larger multicenter cohort studies. Copyright (C) 2020 Wolters Kluwer Health, Inc. All rights reserved.

引用

页码：1775 / 1780

页数：6

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