Role of transforming growth factor beta in peritoneal fibrosis

被引：4
作者：
Al-Jayyousi, RH [1 ]
Medcalf, JF [1 ]
Harris, KP [1 ]
机构：
[1] Leicester Gen Hosp, Dept Nephrol, Renal Unit, Leicester LE5 4PW, Leics, England
来源：
NEPHROLOGY | 2002年 / 7卷 / 05期
关键词：
mesothelial cells; peritoneal fibrosis; transforming growth factor beta;
D O I：
10.1046/j.1440-1797.2002.00116.x
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Technique survival of peritoneal dialysis is seriously limited by the development of peritoneal fibrosis. The mesothelial cell layer lining the peritoneum is important in the pathogenesis of peritoneal fibrosis. Mesothelial cells are able to produce transforming growth factor beta (TGF-beta), and respond to stimulation by this cytokine. In this review, we will detail the evidence available so far for the role of the complex interaction between TGF-beta and mesothelial cells in the development of peritoneal fibrosis.
引用
收藏
页码：216 / 219
页数：4
相关论文
共 29 条
  • [1] Al-Jayyousi Reem H., 2001, Journal of the American Society of Nephrology, V12, p422A
  • [2] ALJAYYOUSI R, 2001, PERITON DIAL INT S2, V21, pS24
  • [3] PERITONEAL-DIALYSIS
    CHAIMOVITZ, C
    [J]. KIDNEY INTERNATIONAL, 1994, 45 (04) : 1226 - 1240
  • [4] Growth-hormone and prolactin excess
    Colao, A
    Lombardi, G
    [J]. LANCET, 1998, 352 (9138) : 1455 - 1461
  • [5] DOBBIE JW, 1992, PERITON DIALYSIS INT, V12, P14
  • [6] Duman S, 2001, PERITON DIALYSIS INT, V21, P219
  • [7] Transforming growth factor-β1 stimulates L-arginine transport and metabolism in vascular smooth muscle cells -: Role in polyamine and collagen synthesis
    Durante, W
    Liao, L
    Reyna, SV
    Peyton, KJ
    Schafer, AI
    [J]. CIRCULATION, 2001, 103 (08) : 1121 - 1127
  • [8] Pentoxifylline inhibits human peritoneal mesothelial cell growth and collagen synthesis:: Effects on TGF-β
    Fang, CC
    Yen, CJ
    Chen, YM
    Sayu, RS
    Tsai, TJ
    Lee, PH
    Hsieh, BS
    [J]. KIDNEY INTERNATIONAL, 2000, 57 (06) : 2626 - 2633
  • [9] Feriani M, 1996, KIDNEY INT, V50, pS75
  • [10] Angiotensin II stimulates collagen synthesis in human vascular smooth muscle cells -: Involvement of the AT1 receptor, transforming growth factor-β, and tyrosine phosphorylation
    Ford, CM
    Li, SH
    Pickering, JG
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1999, 19 (08) : 1843 - 1851
123