Synthesis and Biological Activities of Novel N-Pyridylpyrazole Amide Compounds Carrying Isoxazole Unit

A series of new N-pyridylpyrazole amides bearing substituted isoxazole moiety were designed and prepared based on chlorantraniliprole. These compounds were structurally determined through H-1 NMR, C-13 NMR and elemental analyses. Bioassay results displayed that all designed compounds showed a mortality rate of 100% towards Oriental armyworm at the dosage of 500 mu g/mL. At the dosage of 100 mu g/mL, the mortality rates of four compounds towards Oriental armyworm were 80%similar to 100%. Two compounds had 40%similar to 50% insecticidal activities towards Oriental armyworm at the concentration of 20 mu g/mL. At the concentration of 500 mu g/mL, five compounds demonstrated 90%similar to 100% insecticidal activities against Aphis medicaginis. Moreover, at the dosage of 500 mu g/mL, two compounds exhibited 70%similar to 80% insecticidal activities against Tetranychus cinnabarinus.